A novel device for measuring arterial stiffness using finger-toe pulse wave velocity: Validation study of the pOpmetre®

被引:38
|
作者
Alivon, Maureen [1 ]
Thao Vo-Duc Phuong [1 ]
Vignon, Virginie [1 ]
Bozec, Erwan [2 ]
Khettab, Hakim [1 ]
Hanon, Olivier [3 ]
Briet, Marie [1 ]
Halimi, Jean-Michel [4 ]
Hallab, Magid [5 ]
Plichart, Matthieu [3 ]
Mohammedi, Kamel [6 ]
Marre, Michel [6 ]
Boutouyrie, Pierre [1 ]
Laurent, Stephane [1 ]
机构
[1] Univ Paris 05, AP HP, HEGR, Inserm U970, Paris, France
[2] Hop Vandeouvre Les Nancy, CIC Inserm, Nancy, France
[3] Univ Paris 05, Hop Broca, AP HP, Paris, France
[4] Univ Tours, Dept Nephrol, Tours, France
[5] Univ Nantes, Gerontol Dept, F-44000 Nantes, France
[6] Hop Bichat Claude Bernard, AP HP, Serv Endocrinol Diabetol & Nutr, F-75877 Paris, France
关键词
Arterial stiffness; Pulse wave velocity; Finger-to-toe transit time; EXPERT CONSENSUS DOCUMENT; CARDIOVASCULAR EVENTS; COLD PRESSOR; METAANALYSIS; INDEX; PREDICTION; MORTALITY;
D O I
10.1016/j.acvd.2014.12.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. - The finger-toe pathway could be a good alternative for assessing arterial stiffness conveniently. Aim. - To evaluate the accuracy of the pOpmetre (R) - a new device that measures finger-toe pulse wave velocity (ft-PWV). Methods. - The pOpmetre has two photodiode sensors, positioned on the finger and the toe. Pulse waves are recorded continuously for 20 seconds, and the difference in pulse wave transit time between toe and finger (ft-TT) is calculated. The travelled distance is estimated using subject height. Study 1 compared ft-PWV with carotid-femoral PWV (cf-PWV) obtained by the reference method (SphygmoCor (R)) in 86 subjects (mean age 53 +/- 20 years), including 69 patients with various pathologies and 17 healthy normotensives. Study 2 compared changes in ft-PWV and cf-PWV during a cold pressor test in 10 healthy subjects. Study 3 assessed repeatability in 45 patients. Results. - ft-PWV correlated significantly with cf-PWV (R-2 = 0.43; P < 0.0001). A better correlation was found in terms of transit time (R-2 = 0.61; P < 0.0001). The discrepancy between transit times was related to age. The cold pressor test induced parallel changes in cf-PWV and ft-PWV, with increased aortic stiffness that was reversible during recovery. Intra-session repeatability was very good, with a coefficient of variation of 4.52%. Conclusion. - The pOpmetre (R) allows measurement of arterial stiffness in routine clinical practice. The greatest advantages of ft-PWV are simplicity, rapidity, feasibility, acceptability by patients and correct agreement with the reference technique. Further studies are needed to adjust for bias and to validate the pOpmetre in larger populations. (C) 2015 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:227 / 234
页数:8
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