Precision Medicine in Myeloma: Challenges in Defining an Actionable Approach

被引：4
|
作者：
Gonzalez-Calle, Veronica [1 ]
Keane, Niamh [1 ]
Braggio, Esteban [1 ]
Fonseca, Rafael [1 ]
机构：
[1] Mayo Clin, Div Hematol & Oncol, Scottsdale, AZ USA
来源：
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2017年 / 17卷 / 10期
关键词：
Actionable mutation; Driver; Immunotherapy; Multiple myeloma; Target therapy; INTERNATIONAL STAGING SYSTEM; BRAF V600E MUTATION; MULTIPLE-MYELOMA; T-CELLS; MOLECULAR CLASSIFICATION; REFRACTORY MYELOMA; IMPROVED SURVIVAL; GENE-MUTATIONS; INHIBITOR; CANCER;
D O I：
10.1016/j.clml.2017.06.021
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recently, large sequencing studies have provided insights into the mutational landscape of multiple myeloma (MM), identifying actionable mutations and giving a precious opportunity for exploring new targeted therapies. The main goal of precision medicine, matching patients with the right drug, seems to be closer than ever. However, no targeted therapies in MM are approved yet. Several clinical trials testing targeted drugs and enrolling patients with MM are currently ongoing and will provide predictive biomarkers that might support clinical decision making. In this review, we evaluate the evidence supporting the implementation of precision medicine in MM and we discuss the challenges that should be dealt with in this imminent and promising new era. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：621 / 630
页数：10
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