[DDQM][HSO4]/TBHP as a Multifunctional Catalyst for the Metal Free Tandem Oxidative Synthesis of 2-Phenylquinazolin-4(3H)-ones

被引：14
|
作者：
Dutta, Bidyutjyoti [1 ]
Dutta, Nilakshi [1 ]
Dutta, Apurba [1 ]
Gogoi, Montu [1 ]
Mehra, Sanjay [2 ]
Kumar, Arvind [2 ]
Deori, Kalyanjyoti [1 ]
Sarma, Diganta [1 ]
机构：
[1] Dibrugarh Univ, Dept Chem, Dibrugarh 786004, Assam, India
[2] CSIR Cent Salt & Marine Chem Res Inst, Salt & Marine Chem Div, AcSIR, Bhavnagar 364002, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 88卷 / 20期
关键词：
TEMPERATURE IONIC LIQUIDS; SOLVENTS;
D O I：
10.1021/acs.joc.2c00908
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A bifunctional ionic liquid (IL) [DDQM] [HSO4] has been designed and explored as a three-way catalyst for the synthesis of 2-phenylquinazolin-4(3H)-ones from anthranilamide and benzyl alcohol in 3.5 min incorporating microwave irradiation. Photochemically the reaction proceeds for 4 h at room temperature and thermally for 8 h at 120 degrees C. Further IL-assisted metal, solvent, and base free in situ oxidation of benzyl alcohols to aldehydes shows its task specificity. The multifunctionality of the IL was reestablished with the synthesis of two Wnt pathway antagonists.
引用
收藏
页码：14748 / 14752
页数：5
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