When to Offer Genetic Testing for Pulmonary Arterial Hypertension

被引：8
|
作者：
Chung, Wendy K. [1 ,2 ]
Austin, Eric D. [3 ]
Best, D. Hunter [4 ,5 ]
Brown, Lynette M.
Elliott, C. Gregory [6 ,7 ]
机构：
[1] Columbia Univ Med Ctr, Dept Pediat, New York, NY USA
[2] Columbia Univ Med Ctr, Dept Med, New York, NY USA
[3] Vanderbilt Univ Sch Med, Dept Pediat, Nashville, TN USA
[4] Univ Utah Sch Med, Dept Pathol, Salt Lake City, UT USA
[5] ARUP Labs, ARUP Inst Clin & Expt Pathol, Salt Lake City, UT USA
[6] Intermt Med Ctr, Dept Med, Murray, UT 84107 USA
[7] Univ Utah Sch Med, Dept Med, Salt Lake City, UT USA
来源：
CANADIAN JOURNAL OF CARDIOLOGY | 2015年 / 31卷 / 04期
关键词：
D O I：
10.1016/j.cjca.2014.11.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Genetic testing is poised to play a greater role in the diagnosis and management of pulmonary arterial hypertension (PAH). Physicians who manage PAH should know the heritable PAH phenotypes, inheritance patterns, and responsible genes. They also should know indications, potential risks and benefits, and the issues surrounding genetic counselling and testing for patients with PAH.
引用
收藏
页码：544 / 547
页数：4
相关论文
共 50 条
  • [31] Molecular genetic framework underlying pulmonary arterial hypertension
    Southgate, Laura
    Machado, Rajiv D.
    Graf, Stefan
    Morrell, Nicholas W.
    NATURE REVIEWS CARDIOLOGY, 2020, 17 (02) : 85 - 95
  • [32] A systematic review of genetic mutations in pulmonary arterial hypertension
    Garcia-Rivas, Gerardo
    Jerjes-Sanchez, Carlos
    Rodriguez, David
    Garcia-Pelaez, Jose
    Trevino, Victor
    BMC MEDICAL GENETICS, 2017, 18
  • [33] Genetic diagnostics and molecular approaches in pulmonary arterial hypertension
    Eichstaedt, Christina A.
    Bikou, Olympia
    Sommer, Natascha
    Schermuly, Ralph T.
    Pullamsetti, Soni S.
    Weissmann, Norbert
    Harbaum, Lars
    Tabeling, Christoph
    Wissmueller, Max
    Foris, Vasile
    Kuebler, Wolfgang M.
    Hinderhofer, Katrin
    Olschewski, Andrea
    Kwapiszewska, Grazyna
    PNEUMOLOGIE, 2023, 77 (11): : 862 - 870
  • [34] Molecular genetic framework underlying pulmonary arterial hypertension
    Laura Southgate
    Rajiv D. Machado
    Stefan Gräf
    Nicholas W. Morrell
    Nature Reviews Cardiology, 2020, 17 : 85 - 95
  • [35] Genetic Determinants of Vasodilator Response in Pulmonary Arterial Hypertension
    Karnes, Jason H.
    Thayer, Timothy
    Brittain, Evan
    Batai, Ken
    Arora, Amit
    Cyilmaz, Sultan
    Ayon, Ramon
    Lutz, Katie
    Walsworth, Anna
    Garcia, Joe G.
    Yuan, Jason X.
    Pauciulo, Michael W.
    Nichols, William C.
    Kittles, Rick
    Desai, Ankit
    CIRCULATION, 2018, 138
  • [36] Genetic Determinants of Risk and Survival in Pulmonary Arterial Hypertension
    Rhodes, C. J.
    Batai, K.
    Bleda, M.
    Haimel, M.
    Southgate, L.
    Germain, M.
    Pauciulo, M. W.
    Hadinnapola, C.
    Girerd, B.
    Arora, A.
    Knight, J.
    Hanscombe, K.
    Karnes, J.
    Kaakinen, M.
    Gall, H. H.
    Ulrich, A.
    Harbaum, L.
    Aman, J.
    Cebola, I.
    Ferrer, J.
    Martin, L.
    He, H.
    Frost, A. E.
    White, R.
    Lutz, K.
    Walsworth, A.
    Wharton, J.
    Lawrie, A.
    Humbert, M.
    Soubrier, F.
    Tregouet, D.
    Prokopenko, I.
    Kittles, R.
    Graef, S.
    Nichols, W. C.
    Trembath, R.
    Desai, A. A.
    Morrell, N.
    Wilkins, M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [37] Genetic association of the serotonin transporter in pulmonary arterial hypertension
    Machado, RD
    Koehler, R
    Glissmeyer, E
    Veal, C
    Suntharalingam, J
    Kim, M
    Carlquist, J
    Town, M
    Elliott, CG
    Hoeper, M
    Fijalkowska, A
    Kurzyna, M
    Thomson, JR
    Gibbs, SR
    Wilkins, MR
    Seeger, W
    Morrell, NW
    Gruenig, E
    Trembath, RC
    Janssen, B
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 173 (07) : 793 - 797
  • [38] Sildenafil for pulmonary arterial hypertension: when blue turns into white
    Antoniu, Sabina A.
    EXPERT OPINION ON PHARMACOTHERAPY, 2006, 7 (13) : 1801 - 1810
  • [39] Recently approved drugs offer significant improvements for treatment options in pulmonary arterial hypertension
    不详
    Drugs & Therapy Perspectives, 2006, 22 (4) : 11 - 15
  • [40] Pulmonary vasodilator testing and use of calcium channel blockers in pulmonary arterial hypertension
    Tonelli, Adriano R.
    Alnuaimat, Hassan
    Mubarak, Kamal
    RESPIRATORY MEDICINE, 2010, 104 (04) : 481 - 496
12345