Pseudomembranous Invasive Tracheobronchial Aspergillosis with Fulminant Hepatitis and Hemophagocytic Syndrome

被引:4
|
作者
Majima, Suguru [1 ]
Okachi, Shotaro [1 ]
Asano, Motoyo [2 ]
Wakahara, Keiko [1 ]
Hashimoto, Naozumi [1 ]
Sato, Mitsuo [1 ]
Ishigami, Masatoshi [3 ]
Hasegawa, Yoshinori [1 ]
机构
[1] Nagoya Univ, Grad Sch Med, Dept Resp Med, Nagoya, Aichi, Japan
[2] Kariya Toyota Gen Hosp, Dept Resp Med & Allergol, Kariya, Aichi, Japan
[3] Nagoya Univ, Sch Med, Dept Gastroenterol & Hepatol, Nagoya, Aichi, Japan
关键词
invasive tracheobronchial aspergillosis; fulminant hepatitis; hemophagocytic syndrome; bronchoscopy; LUNG-TRANSPLANT RECIPIENTS; INFECTIONS; MINOCYCLINE; MANAGEMENT; FAILURE;
D O I
10.2169/internalmedicine.9673-17
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Invasive tracheobronchial aspergillosis (ITBA), a rare form of invasive pulmonary Aspergillus infection (IPA), is predominantly confined to the tracheobronchial tree. We herein report a case of ITBA with severe necrotic pseudomembrane in a 57-year-old woman with fulminant hepatitis and hemophagocytic syndrome. Bronchoscopic findings revealed a widespread pseudomembranous formation of the trachea and bronchi. Aspergillus fumigants was cultured from bronchial lavage fluid, and the histological findings of an endobronchial biopsy revealed necrosis and invasive hyphae. Although she responded to antifungal treatment, she ultimately died of a septic shock with Burkholderia cepacia 57 days after admission.
引用
收藏
页码:2371 / 2375
页数:5
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