Effects of early-life malnutrition on neurodevelopment and neuropsychiatric disorders and the potential mechanisms

被引：43
|
作者：
Yan, Xintian [1 ,2 ]
Zhao, Xinzhi [4 ,6 ]
Li, Juxue [5 ]
He, Lin [1 ,2 ,3 ]
Xu, Mingqing [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Minist Educ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China
[3] Fudan Univ, Inst Biomed Sci, Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China
[4] Fudan Univ, Children Hosp, Shanghai, Peoples R China
[5] Nanjing Med Univ, Dept Biochem & Mol Biol, Key Lab Human Funct Genom Jiangsu Prov, Nanjing, Jiangsu, Peoples R China
[6] Shanghai Key Lab Prevent & Intervent Birth Defect, Shanghai, Peoples R China
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2018年 / 83卷
关键词：
Early life; Malnutrition; Neurodevelopment; Neuropsychiatric disorders; Genetic mutation; Epigenetics; Precision nutrition; PRENATAL PROTEIN-MALNUTRITION; MATERNAL NUTRIENT RESTRICTION; PITUITARY-ADRENAL AXIS; DNA METHYLATION; SPATIAL MEMORY; FATTY-ACIDS; VITAMIN-D; FOLATE-DEFICIENCY; DOCOSAHEXAENOIC ACID; ADULT SCHIZOPHRENIA;
D O I：
10.1016/j.pnpbp.2017.12.016
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Lines of evidence have demonstrated that early-life malnutrition is highly correlated with neurodevelopment and adulthood neuropsychiatric disorders, while some findings are conflicting with each other. In addition, the biological mechanisms are less investigated. We systematically reviewed the evidence linking early-life nutrition status with neurodevelopment and clinical observations in human and animal models. We summarized the effects of special nutritious on neuropsychiatric disorders and explored the underlying potential mechanisms. The further understanding of the biological regulation of early-life nutritional status on neurodevelopment might shed light on precision nutrition at an integrative systems biology framework.
引用
收藏
页码：64 / 75
页数：12
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