Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20

被引：81
|
作者：
Hadjihannas, Michel V. [1 ]
Bernkopf, Dominic B. [1 ]
Brueckner, Martina [1 ]
Behrens, Juergen [1 ]
机构：
[1] Univ Erlangen Nurnberg, Nikolaus Fiebiger Ctr Mol Med, D-91054 Erlangen, Germany
来源：
EMBO REPORTS | 2012年 / 13卷 / 04期
关键词：
axin; 2; beta-catenin; cell cycle; CDC20; Wnt signalling; PHOSPHORYLATED BETA-CATENIN; CHROMOSOMAL INSTABILITY; FUNCTIONAL INTERACTION; UP-REGULATION; WNT; CANCER; GROWTH; TRANSCRIPTION; INHIBITION; ACTIVATION;
D O I：
10.1038/embor.2012.12
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Wnt/beta-catenin signalling regulates cell proliferation by modulating the cell cycle and is negatively regulated by conductin/axin2/axil. We show that conductin levels peak at G2/M followed by a rapid decline during return to G1. In line with this, Wnt/beta-catenin target genes are low at G2/M and high at G1/S, and beta-catenin phosphorylation oscillates during the cell cycle in a conductin-dependent manner. Conductin is degraded by the anaphase-promoting complex/cyclosome cofactor CDC20. Knockdown of CDC20 blocks Wnt signalling through conductin. CDC20-resistant conductin inhibits Wnt signalling and attenuates colony formation of colorectal cancer cells. We propose that CDC20-mediated degradation of conductin regulates Wnt/beta-catenin signalling for maximal activity during G1/S.
引用
收藏
页码：347 / 354
页数：8
相关论文
共 50 条
  • [21] Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/β-catenin signaling
    Lim, Xinhong
    Tan, Si Hui
    Yu, Ka Lou
    Lim, Sophia Beng Hui
    Nusse, Roeland
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (11) : E1498 - E1505
  • [22] Truncated APC & AXIN2 expression contribute to maintaining β-catenin/WNT signaling at the "Just Right" level for CRC cell proliferation.
    Zhang, Chi
    Facey, Caroline O.
    Funk, Katherine
    Opdenaker, Lynn M.
    Boman, Bruce M.
    CANCER RESEARCH, 2022, 82 (12)
  • [23] miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2
    Hsin-Yi Chen
    Yaw-Dong Lang
    Han-Nan Lin
    Yun-Ru Liu
    Chun-Chieh Liao
    André Wendindondé Nana
    Yun Yen
    Ruey-Hwa Chen
    Scientific Reports, 9
  • [24] miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2
    Chen, Hsin-Yi
    Lang, Yaw-Dong
    Lin, Han-Nan
    Liu, Yun-Ru
    Liao, Chun-Chieh
    Nana, Andre Wendindonde
    Yen, Yun
    Chen, Ruey-Hwa
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [25] Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of β-catenin in proliferation and differentiation
    Liu, Bo
    Yu, Hsiao-Man Ivy
    Hsu, Wei
    DEVELOPMENTAL BIOLOGY, 2007, 301 (01) : 298 - 308
  • [26] Cell division cycle 20 (CDC20) drives prostate cancer progression via stabilization of β-catenin in cancer stem-like cells
    Zhang, Qin
    Huang, Hai
    Liu, Ao
    Li, Jiang
    Liu, Chunying
    Sun, Bin
    Chen, Lu
    Gao, Yi
    Xu, Danfeng
    Su, Changqing
    EBIOMEDICINE, 2019, 42 : 397 - 407
  • [27] Cdc20: A WD40 activator for a cell cycle degradation machine
    Yu, Hongtao
    MOLECULAR CELL, 2007, 27 (01) : 3 - 16
  • [28] Cdc20 control of cell fate during prolonged mitotic arrest
    Nilsson, Jakob
    BIOESSAYS, 2011, 33 (12) : 903 - 909
  • [29] The role of CDC20 isoforms in A-thaliana cell cycle regulation and development
    Kroll, A
    Kevei, Z
    Kelemen, Z
    Kondorosi, E
    Kondorosi, A
    FEBS JOURNAL, 2005, 272 : 455 - 456
  • [30] HMGN2 accelerates the proliferation and cell cycle progression of glioblastoma by regulating CDC20 expression
    Zhong, Jiacheng
    Shi, Shuang
    Peng, Wen
    Cui, Hongjuan
    Sun, Xiaochuan
    GENES & DISEASES, 2025, 12 (03)
12345