Sensitive periods for the effect of childhood interpersonal violence on psychiatric disorder onset among adolescents

被引:17
|
作者
Dunn, Erin C. [1 ,2 ]
Wang, Yan [3 ]
Tse, Jenny [4 ]
McLaughlin, Katie A. [5 ]
Fitzmaurice, Garrett [6 ,7 ]
Gilman, Stephen E. [4 ,8 ,9 ]
Susser, Ezra S. [10 ,11 ]
机构
[1] Harvard Med Sch, Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Dept Psychiat, Boston, MA USA
[2] Broad Inst Harvard & MIT, Stanley Ctr Psychiat Res, Cambridge, MA USA
[3] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA
[4] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
[5] Univ Washington, Dept Psychol, Seattle, WA 98195 USA
[6] Harvard Med Sch, Dept Psychiat, McLean Hosp, Lab Psychiat Biostat, Belmont, MA USA
[7] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA
[8] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA
[9] Eunice Kennedy Shrivel Natl Inst Child Hlth & Hum, Hlth Behav Branch, Div Intramural Populat Hlth Res, Rockville, MD USA
[10] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA
[11] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
基金
美国国家卫生研究院;
关键词
POSTTRAUMATIC-STRESS-DISORDER; DEVELOPMENTAL PSYCHOPATHOLOGY PERSPECTIVE; DSM-IV DISORDERS; SEXUAL-ABUSE; GENDER-DIFFERENCES; MAJOR DEPRESSION; EARLY-LIFE; MALTREATMENT; BRAIN; ADVERSITIES;
D O I
10.1192/bjp.bp.117.208397
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background Although childhood adversity is a strong determinant of psychopathology, it remains unclear whether there are 'sensitive periods' when a first episode of adversity is most harmful. Aims To examine whether variation in the developmental timing of a first episode of interpersonal violence (up to age 18) associates with risk for psychopathology. Method Using cross-sectional data, we examined the association between age at first exposure to four types of interpersonal violence (physical abuse by parents, physical abuse by others, rape, and sexual assault/molestation) and onset of four classes of DSM-IV disorders (distress, fear, behaviour, substance use) (n=9984). Age at exposure was defined as: early childhood (ages 0-5), middle childhood (ages 6-10) and adolescence (ages 11-18). Results Exposure to interpersonal violence at any age period about doubled the risk of a psychiatric disorder (odds ratios (ORs)=1.51-2.52). However, few differences in risk were observed based on the timing of first exposure. After conducting 20 tests of association, only three significant differences in risk were observed based on the timing of exposure; these results suggested an elevated risk of behaviour disorder among youth first exposed to any type of interpersonal violence during adolescence (OR=2.37, 95% Cl 1.69-3.34), especially being beaten by another person (OR=2.44; 95% CI 1.57-3.79), and an elevated risk of substance use disorder among youth beaten by someone during adolescence (OR=2.77, 95% 01 194-396). Conclusions Children exposed to interpersonal violence had an elevated risk of psychiatric disorder. However, age at first episode of exposure was largely unassociated with psychopathology risk.
引用
收藏
页码:365 / +
页数:18
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