Ghrelin induces growth hormone (GH) secretion via nitric oxide (NO)/cGMP signaling

被引：19

作者：

Rodríguez-Pacheco, F ^{[1
]}

Luque, RM ^{[1
]}

García-Navarro, S ^{[1
]}

Gracia-Navarro, F ^{[1
]}

Castaño, JP ^{[1
]}

Malagón, MM ^{[1
]}

机构：

[1] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba 14014, Spain

来源：

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY | 2005年 / 1040卷

关键词：

ghrelin; GH secretion; NO; cGMP;

D O I：

10.1196/annals.1327.087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ghrelin, a recently discovered 28-aa peptide, stimulates GH release through a mechanism involving PLC- and cAMP-related signaling pathways. Recently, nitric oxide (NO) and its mediator, cGMP, have been shown to be required for the response of somatotropes to various regulators (GHRH, somatostatin, leptin). Here, we explore the possible role of the NO synthase (NOS)/NO/guanylate cyclase (GC)/cGMP signaling pathway in ghrelin-induced GH release from cultured pig somatotropes using blockers or activators of this route.

引用

页码：452 / 453

页数：2

共 50 条

[31] Leptin induces growth hormone secretion from peripheral blood mononuclear cells via a protein kinase C- and nitric oxide-dependent mechanism
Dixit, VD
Mielenz, M
Taub, DD
Parvizi, N
ENDOCRINOLOGY, 2003, 144 (12) : 5595 - 5603
[32] A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans
Hataya, Y
Akamizu, T
Takaya, K
Kanamoto, N
Ariyasu, H
Saijo, M
Moriyama, K
Shimatsu, A
Kojima, M
Kangawa, K
Nakao, K
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (09): : 4552 - 4555
[33] Nitric oxide/cGMP signaling in the corpora allata of female grasshoppers
Wirmer, Andrea
Heinrich, Ralf
JOURNAL OF INSECT PHYSIOLOGY, 2011, 57 (01) : 94 - 107
[34] Ghrelin and growth hormone secretagogues (GHS): Modulation of growth hormone secretion and therapeutic applications
Correa-Silva, Sam R.
Paiva Cunha De Sa, Larissa Bianca
Lengyel, Ana-Maria J.
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA, 2008, 52 (05) : 726 - 733
[35] Role of growth hormone (GH)-releasing hormone and somatostatin on leptin-induced GH secretion
Carro, E
Señarís, RM
Seoane, LM
Frohman, LA
Arimura, A
Casanueva, FF
Diéguez, C
NEUROENDOCRINOLOGY, 1999, 69 (01) : 3 - 10
[36] RESEARCH CONCERNING CONTROL OF SECRETION OF GROWTH HORMONE (GH)
PECILE, A
MULLER, E
PATHOLOGIE BIOLOGIE, 1967, 15 (3-4): : 189 - &
[37] Regulation of gastric ghrelin secretion by nitric oxide (NO) derived from neuronal nitric oxide synthase (nNOS)
Masaoka, Tatsuhiro
Suzuki, Hidekazu
Minegishi, Yuriko
Takahashi, Tetsufumi
Iwasaki, Eisuke
Suematsu, Makoto
Hosoda, Hiroshi
Kangawa, Kenji
Hibi, Toshifumi
GASTROENTEROLOGY, 2007, 132 (04) : A118 - A118
[38] Nocturnal growth hormone (GH) secretion is eliminated by infusion of GH-Releasing hormone antagonist
OcampoLim, B
Guo, WS
DeMottFriberg, R
Barkan, AL
Jaffe, CA
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (12): : 4396 - 4399
[39] INFLUENCE OF CARBAMAZEPINE ON SECRETION OF GROWTH-HORMONE (GH)
UHLICH, E
WERDER, KV
KLINISCHE WOCHENSCHRIFT, 1972, 50 (20): : 981 - &
[40] Nitric oxide synthase and cGMP-mediated stimulation of renin secretion
Sayago, CM
Beierwaltes, WH
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 281 (04) : R1146 - R1151

← 1 2 3 4 5 →