Cost-effectiveness of universal childhood hepatitis A vaccination in Chile

被引：44

作者：

Valenzuela, MT

Jacobs, RJ ^{[1
]}

Arteaga, O

Navarrete, MS

Meyerhoff, AS

Innis, BL

机构：

[1] Univ Chile, Fac Med, Sch Publ Hlth, Santiago, Chile

[2] Capitol Outcomes Res Inc, Alexandria, VA 22310 USA

[3] GlaxoSmithKline, Santiago, Chile

[4] GlaxoSmithKline, King Of Prussia, PA USA

来源：

VACCINE | 2005年 / 23卷 / 32期

关键词：

cost and cost analysis; hepatitis A; vaccination;

D O I：

10.1016/j.vaccine.2005.03.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hepatitis A is an important public health problem in Chile. Childhood vaccination has reduced hepatitis A rates in several countries, prompting this evaluation of its cost-effectiveness in Chile. Using a Markov model, we project mass vaccination would reduce hepatitis A cases among birth cohort members and their personal contacts > 80%. Vaccination costs of US$ 5.3-6.4 million would be offset by US$ 9.2-9.4 million reductions in disease costs. Further, approximately 70 fatal infections would be averted and > 4600 quality-adjusted life years would be saved. This analysis supports the cost-effectiveness of universal childhood hepatitis A vaccination in Chile. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4110 / 4119

页数：10

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