Cost-effectiveness analysis of universal childhood vaccination against varicella in Brazil

被引：38

作者：

Valentim, J. ^{[1
]}

Sartori, A. M. C. ^{[2
]}

de Soarez, P. C. ^{[1
]}

Amaku, M. ^{[3
]}

Azevedo, R. S. ^{[4
]}

Novaes, H. M. D. ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Med, Dept Prevent Med, BR-01246903 Sao Paulo, Brazil

[2] Univ Sao Paulo, Sch Med, Hosp Clin, Clin Infect & Parasit Dis, BR-05403000 Sao Paulo, Brazil

[3] Univ Sao Paulo, Sch Vet Med, Dept Vet Prevent Med, BR-05508270 Sao Paulo, Brazil

[4] Univ Sao Paulo, Sch Med, Dept Pathol, BR-01246903 Sao Paulo, Brazil

来源：

VACCINE | 2008年 / 26卷 / 49期

关键词：

Varicella vaccine; Cost-effectiveness; Brazil;

D O I：

10.1016/j.vaccine.2008.07.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study conducts a cost-effectiveness analysis of a childhood universal varicella vaccination program in Brazil. An age and time-dependent dynamic model was developed to estimate the incidence of varicella for 30 years. Assuming a single-dose schedule; vaccine efficacy of 85% and coverage of 80%, the program could prevent 74,422,058 cases and 2905 deaths. It would cost R$ 3,178,396,110 and save R$ 660,076,410 to the society and R$ 365,602,305 to the healthcare system. The program is cost-effective (R$ 14,749 and R$ 16,582 per life-year saved under the societal and the healthcare system's perspective, respectively). The program's cost-effectiveness is highly sensitive to the vaccine price and number of doses. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6281 / 6291

页数：11

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