Reactions of 1-amino-5-morpholino-6,7,8,9-tetrahydrothieno[2,3-c] isoquinoline-2-carbonitrile

被引：9
|
作者：
El-Dean, Adel M. Kamal [1 ]
Radwan, Shaban M. [1 ]
Zaki, Remon M. [1 ]
机构：
[1] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt
来源：
JOURNAL OF CHEMICAL RESEARCH | 2010年 / 10期
关键词：
tetrahydroisoquinoline; thienotetrahydroisoquinoline pyrimidothieno-tetrahydroisoquinoline; triazolopyrimidothienotetrahydroisoquinoline; ANTI-HIV AGENTS; 3-SUBSTITUTED PYRIDO<3',2'-4,5>THIENO<3,2-D>PYRIMIDIN-4(3H)-ONES; IN-VITRO; ALKALOIDS; ANTIMALARIAL; ISOQUINOLINE; DERIVATIVES; ANTAGONISTS;
D O I：
10.3184/030823410X12868184096970
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
1-Amino-5-morpholino-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carbonitrile has been converted to the chloroacetylamino derivative which was subjected to nucleophilic substitution reactions with different amines. Reaction of 1-amino-5-morpholino-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carbonitrile with triethyl orthoformate followed by cyclisation with hydrazine yielded an aminoiminopyrimidine derivative. The latter was used as a starting material for the synthesis of a variety of fused heterocyclic compounds which include triazolopyrimidothienotetrahydroisoquinolines.
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页码：596 / 602
页数：7
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