New 4α-methyl steroids from a Chinese soft coral Nephthea sp.

被引：19
|
作者：
Ma, Ke
Li, Wei
Fu, Hongwei
Koike, Kazuo
Lin, Wenhan
van Ofwegen, Leen P.
Fu, Hongzheng
机构：
[1] Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
[2] Toho Univ, Fac Pharmaceut Sci, Chiba 2748510, Japan
[3] Natl Museum Nat Hist Naturalis, NL-2300 RA Leiden, Netherlands
来源：
STEROIDS | 2007年 / 72卷 / 14期
基金：
中国国家自然科学基金;
关键词：
soft coral; Nephthea sp; 4 alpha-methyl steroids; Polyoxygenated steroids;
D O I：
10.1016/j.steroids.2007.07.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three new 4 alpha-methyl steroids, 4 alpha-methyl-ergost-7,24(28)-diene-3 beta-ol-23-one (1), 4 alpha-methyl-ergost-8 (14),24(28)-diene-3 beta-ol-23-one (2), 4 alpha-methyl-ergost-24(28)-en-3 beta,11 beta-diol-23-one (3), and two new polyoxygenated steroids, ergost-5,25-diene-3 beta,24S,28-triol (4), ergost-5,24(28)-diene-3 beta,23S-diol (5), along with one known steroid 24-methylencholesterol (6) were isolated from the soft coral Nephthea sp. Their structures including the relative configurations were elucidated by extensive 1D and 2D NMR spectra analysis. The absolute configurations of (4) and (5) were determined by the Mosher's method. (c) 2007 Published by Elsevier Inc.
引用
收藏
页码：901 / 907
页数：7
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