New cytotoxic constituents from the Red Sea soft coral Nephthea sp.

被引：23

作者：

Hegazy, Mohamed-Elamir F. ^{[1
,2
]}

Gamal-Eldeen, Amira M. ^{[3
,4
]}

Mohamed, Tarik A. ^{[1
,2
]}

Alhammady, Montaser A. ^{[5
]}

Hassanien, Abuzeid A. ^{[6
]}

Shreadah, Mohamed A.

Abdelgawad, Ibrahim I. ^{[6
]}

Elkady, Eman M. ^{[7
]}

Pare, Paul W. ^{[7
,8
]}

机构：

[1] Natl Res Ctr, Phytochem Dept, 33 El Bohouth St Former El Tahrir St,POB 12622, Giza, Egypt

[2] Natl Res Ctr, Ctr Excellence Adv Sci, 33 El Bohouth St Former El Tahrir St,POB 12622, Giza, Egypt

[3] Natl Res Ctr, Ctr Excellence Adv Sci, Canc Biol Lab, 33 El Bohouth St Former El Tahrir St,POB 12622, Giza, Egypt

[4] Natl Res Ctr, Dept Biochem, 33 El Bohouth St Former El Tahrir St,POB 12622, Giza, Egypt

[5] Natl Inst Oceanog & Fisheries, Red Sea Branch, Hurghada 84511, Egypt

[6] Suez Univ, Fac Sci, Dept Chem, Cairo, Egypt

[7] Natl Inst Oceanog & Fisheries, Alexandria, Egypt

[8] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 11期

关键词：

Nephthea sp; terpenes; cytotoxicity; breast cancer cell line MCF-7; STEROLS;

D O I：

10.1080/14786419.2015.1055266

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Nephthea are soft coral species rich in sesquiterpenoids and steroids. An organic extract of Nephthea sp. resulted in the isolation of a new steroid (1), as well as several previously reported metabolites (2-9). Structures were elucidated by employing NMR and HR-EI-MS analyses. The total extract, fractions and purified compounds exhibited differential cytotoxicity against the breast cancer MCF-7 cell line.

引用

页码：1266 / 1272

页数：7

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