Urinary metabolites of genistein administered orally to rats

被引：17
|
作者：
Yasuda, T [1 ]
Ueda, J [1 ]
Ohsawa, K [1 ]
机构：
[1] Tohoku Pharmaceut Univ, Aoba Ku, Sendai, Miyagi 9818558, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 11期
关键词：
genistein; urinary metabolite; 4 ',5,7-trihydroxyisoflavanone; 4; 7-dihydroxyisoflavan; equol; p-ethylphenol;
D O I：
10.1248/cpb.49.1495
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In a study on the metabolism of flavonoids, the isoflavone genistein was administered orally to rats. Urine samples were collected and treated with beta -glucuronidase and arylsulfatase. Genistein and its metabolites, 4 ' ,5,7-trihydroxyisoflavanone (MI), 4 ' ,7-dihydroxyisoflavan (M2), and p-ethylphenol (M3) were isolated from the urine following treatment with enzymes. The structures of M1, M2, and M3 were determined on the basis of chemical and spectral data.
引用
收藏
页码：1495 / 1497
页数：3
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