Brain-derived neurotrophic factor and mental illness: An epigenetic approach

被引：0

作者：

Starkman, Bela G. ^{[1
]}

Pandey, Subhash C. ^{[1
]}

机构：

[1] Univ Illinois, Dept Psychiat Anat & Cell Biol, Chicago & Jesse Brown VA Med Ctr, Chicago, IL 60612 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES INDIA SECTION B-BIOLOGICAL SCIENCES | 2007年 / 77卷

关键词：

BDNF; epigenetics; histones; drug addiction; alcoholism;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Brain-derived neurotrophic factor (BDNF) is one of the neurotrophins implicated in the impaired synaptic plasticity associated with brain disorders. Recent evidence indicates that epigenetic mechanisms, such as chromatin remodeling via histone acetylation and DNA methylation, may play an important role in the regulation of gene expression, including that of bdnf, in the brain. This review takes a comprehensive approach in discussing the role of epigenetics in the regulation of bdnf expression in the brain during various CNS disorders, such as cognitive, psychiatric, and addictive behaviors.

引用

页码：105 / 113

页数：9

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