Inositolphosphoglycans are possible mediators of the glucagon-like peptide 1 (7-36)amide action in the liver

被引：27

作者：

Trapote, MA ^{[1
]}

Clemente, F ^{[1
]}

Galera, C ^{[1
]}

Morales, M ^{[1
]}

Alcantara, AI ^{[1
]}

LopezDelgado, MI ^{[1
]}

VillanuevaPenacarrillo, ML ^{[1
]}

Valverde, I ^{[1
]}

机构：

[1] FDN JIMENEZ DIAZ,DEPT METAB NUTR & HORMONAS,E-28040 MADRID,SPAIN

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 1996年 / 19卷 / 02期

关键词：

HEP G-2 cells; GCP-1(7-36)amide; inositolphosphoglycans (IPGs); glycosilphosphatidilinositols (GPIs); glycogenesis; glycogen-synthase;

D O I：

10.1007/BF03349846

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A potent glycogenic effect for GLP-1(7-36)amide has been found in rat hepatocytes and skeletal muscle, and the specific receptors detected for GLP-1(7-36)amide in these tissue membranes do not seem to be associated to adenylate cyclase. On the other hand, inositolphosphoglycan molecules (IPGs) have been implicated as second messengers in the action of insulin. In a human hepatoma cell line (HEP G-2), we have observed the presence of [I-125]GLP-1(7-36)amide specific binding, and a stimulatory effect of the peptide upon glycogen synthesis, confirming the findings in isolated rat hepatocytes. Also, GLP-1(7-36)amide modulates the cell content of radiolabelled glycosylphosphatidylinositols (GPIs), in the same manner as insulin, indicating hydrolysis of GPIs and an immediate and short-lived generation of IPGs. Thus, IPGs could be mediators in the GLP-1(7-36)amide glycogenic action in the liver.

引用

页码：114 / 118

页数：5

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