Apoptosis, airway inflammation and anti-asthma therapy: From immunobiology to clinical application

被引：17
|
作者：
Spinozzi, Fabrizio [2 ]
de Benedictis, Diletta [3 ]
de Benedictis, F. M. [1 ]
机构：
[1] Salesi Childrens Hosp, Dept Pediat, I-60123 Ancona, Italy
[2] Univ Perugia, Dept Clin & Expt Med, I-06100 Perugia, Italy
[3] Univ Perugia, Dept Pediat, I-06100 Perugia, Italy
来源：
PEDIATRIC ALLERGY AND IMMUNOLOGY | 2008年 / 19卷 / 04期
关键词：
apoptosis; airway inflammation; asthma;
D O I：
10.1111/j.1399-3038.2007.00668.x
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
T lymphocyte apoptosis is essential for maintaining immune system homeostasis. Experimental evidence suggests apoptosis control mechanisms may be impaired in inflammatory conditions, particularly airway Th2-type allergic diseases. This review briefly examines the mucosal immune system homeostasis and common apoptotic pathways and discusses impaired apoptosis, allergy, airway inflammation, remodelling and fibrosis. Finally, the paper presents an update on pharmacological targeting of apoptosis to control airway inflammation in patients with allergic asthma.
引用
收藏
页码：287 / 295
页数：9
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