Suboptimal Response to Coronavirus Disease 2019 Messenger RNA Vaccines in Patients With Hematologic Malignancies: A Need for Vigilance in the Postmasking Era

被引：52
|
作者：
Agha, Mounzer E. [1 ]
Blake, Maggie [1 ]
Chilleo, Charles [3 ]
Wells, Alan [2 ]
Haidar, Ghady [4 ]
机构：
[1] Univ Pittsburgh, Med Ctr, Hillman Canc Ctr, Pittsburgh, PA USA
[2] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA
[3] Univ Pittsburgh, Med Ctr, Clin Labs, Pittsburgh, PA USA
[4] Univ Pittsburgh, Div Infect Dis, Sch Med, Pittsburgh, PA USA
来源：
OPEN FORUM INFECTIOUS DISEASES | 2021年 / 8卷 / 07期
基金：
美国国家卫生研究院;
关键词：
antibody; COVID; 19; vaccine; hematological malignancy; SARS; CoV; 2; COVID-19;
D O I：
10.1093/ofid/ofab353
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We measured severe acute respiratory syndrome coronavirus 2 immunoglobulin G responses in 67 patients with hematological malignancies after 2 messenger RNA vaccine doses. Forty-six percent were nonresponders; patients with B-cell chronic lymphocytic leukemia were at highest risk (77% nonresponders). Patients with hematological malignancies should continue wearing masks and socially distancing. Studies of revaccination, boosters, and humoral immune correlates of protection are needed.
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页数：5
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