Effectiveness of Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccines for Preventing Coronavirus Disease 2019 Hospitalizations in the United States

被引：0

作者：

Tenforde, Mark W. ^{[1
]}

Patel, Manish M. ^{[1
]}

Ginde, Adit A. ^{[2
]}

Douin, David J. ^{[3
]}

Talbot, H. Keipp ^{[4
]}

Casey, Jonathan D. ^{[5
]}

Mohr, Nicholas M. ^{[6
]}

Zepeski, Anne ^{[6
]}

Gaglani, Manjusha ^{[7
]}

McNeal, Tresa ^{[7
]}

Ghamande, Shekhar ^{[7
]}

Shapiro, Nathan, I ^{[8
]}

Gibbs, Kevin W. ^{[9
]}

Files, D. Clark ^{[9
]}

Hager, David N. ^{[10
]}

Shehu, Arber ^{[10
]}

Prekker, Matthew E. ^{[11
]}

Erickson, Heidi L. ^{[12
]}

Exline, Matthew C. ^{[13
]}

Gong, Michelle N. ^{[14
]}

Mohamed, Amira ^{[15
]}

Henning, Daniel J. ^{[16
]}

Steingrub, Jay S. ^{[17
]}

Peltan, Ithan D. ^{[18
,19
]}

Brown, Samuel M. ^{[18
,19
]}

Martin, Emily T. ^{[20
]}

Monto, Arnold S. ^{[20
]}

Khan, Akram ^{[21
]}

Hough, Catherine L. ^{[21
]}

Busse, Laurence W. ^{[22
]}

ten Lohuis, Caitlin C. ^{[23
]}

Duggal, Abhijit ^{[24
]}

Wilson, Jennifer G. ^{[25
]}

Gordon, Alexandra June ^{[25
]}

Qadir, Nida ^{[26
]}

Chang, Steven Y. ^{[26
]}

Mallow, Christopher ^{[27
]}

Gershengorn, Hayley B. ^{[27
]}

Babcock, Hilary M. ^{[28
]}

Kwon, Jennie H. ^{[28
]}

Halasa, Natasha ^{[29
]}

Chappell, James D. ^{[29
]}

Lauring, Adam S. ^{[30
,31
]}

Grijalva, Carlos G. ^{[5
]}

Rice, Todd W. ^{[5
]}

Jones, Ian D. ^{[32
]}

Stubblefield, William B. ^{[32
]}

Baughman, Adrienne ^{[32
]}

Womack, Kelsey N. ^{[33
]}

Lindsell, Christopher J. ^{[34
]}

机构：

[1] CDC COVID 19 Response Team, Atlanta, GA USA

[2] Univ Colorado, Sch Med, Dept Emergency Med, Aurora, CO USA

[3] Univ Colorado, Dept Anesthesiol, Sch Med, Aurora, CO USA

[4] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA

[5] Vanderbilt Univ, Med Ctr, Dept Hlth Policy, Nashville, TN 37232 USA

[6] Univ Iowa, Dept Emergency Med, Iowa City, IA USA

[7] Texas A&M Univ, Coll Med, Baylor Scott & White Hlth, Temple, TX 76508 USA

[8] Beth Israel Deaconess Med Ctr, Dept Emergency Med, Boston, MA 02215 USA

[9] Wake Forest Sch Med, Dept Med, Winston Salem, NC 27101 USA

[10] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[11] Hennepin Cty Med Ctr, Dept Emergency Med & Med, Minneapolis, MN 55415 USA

[12] Hennepin Cty Med Ctr, Dept Med, Minneapolis, MN 55415 USA

[13] Ohio State Univ, Dept Med, Columbus, OH 43210 USA

[14] Albert Einstein Coll Med, Dept Med, Montefiore Hlth Syst, Bronx, NY USA

[15] Montefiore Med Ctr, Dept Med, Bronx, NY 10467 USA

[16] Univ Washington, Dept Emergency Med, Seattle, WA 98195 USA

[17] Baystate Med Ctr, Dept Med, Springfield, MA 01199 USA

[18] Intermt Med Ctr, Dept Med, Murray, UT USA

[19] Univ Utah, Salt Lake City, UT USA

[20] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA

[21] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA

[22] Emory Univ, Dept Med, Atlanta, GA 30322 USA

[23] Emory Healthcare, Emory Crit Care Ctr, Atlanta, GA USA

[24] Cleveland Clin, Dept Med, Cleveland, OH 44106 USA

[25] Stanford Univ, Dept Emergency Med, Sch Med, Stanford, CA 94305 USA

[26] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA

[27] Univ Miami, Dept Med, Miami, FL USA

[28] Washington Univ, Dept Med, St Louis, MO USA

[29] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA

[30] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[31] Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

[32] Vanderbilt Univ, Dept Emergency Med, Med Ctr, Nashville, TN 37232 USA

[33] Vanderbilt Univ, Med Ctr, Vanderbilt Inst Clin & Translat Res, Nashville, TN 37232 USA

[34] Vanderbilt Univ, Dept Biostat, Med Ctr, Nashville, TN 37232 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2022年 / 74卷 / 09期

基金：

美国国家卫生研究院;

关键词：

COVID-19; vaccine effectiveness; mRNA vaccines; hospitalized; immunocompromised; TEST-NEGATIVE DESIGN; SARS-COV-2; INFECTION; COVID-19;

D O I：

10.1093/cid/ciab687

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

From March to May 2021, full vaccination using authorized mRNA products was associated with 87.1% (95% CI, 80.7-91.3) protection against COVID-19 hospitalization among US adults. Vaccine effectiveness was lower in adults with versus without immunosuppression (62.9% versus 91.3%). Background As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination coverage increases in the United States, there is a need to understand the real-world effectiveness against severe coronavirus disease 2019 (COVID-19) and among people at increased risk for poor outcomes. Methods In a multicenter case-control analysis of US adults hospitalized March 11-May 5, 2021, we evaluated vaccine effectiveness to prevent COVID-19 hospitalizations by comparing odds of prior vaccination with a messenger RNA (mRNA) vaccine (Pfizer-BioNTech or Moderna) between cases hospitalized with COVID-19 and hospital-based controls who tested negative for SARS-CoV-2. Results Among 1212 participants, including 593 cases and 619 controls, median age was 58 years, 22.8% were Black, 13.9% were Hispanic, and 21.0% had immunosuppression. SARS-CoV-2 lineage B0.1.1.7 (Alpha) was the most common variant (67.9% of viruses with lineage determined). Full vaccination (receipt of 2 vaccine doses >= 14 days before illness onset) had been received by 8.2% of cases and 36.4% of controls. Overall vaccine effectiveness was 87.1% (95% confidence interval [CI], 80.7-91.3). Vaccine effectiveness was similar for Pfizer-BioNTech and Moderna vaccines, and highest in adults aged 18-49 years (97.4%; 95% CI, 79.3-9.7). Among 45 patients with vaccine-breakthrough COVID hospitalizations, 44 (97.8%) were >= 50 years old and 20 (44.4%) had immunosuppression. Vaccine effectiveness was lower among patients with immunosuppression (62.9%; 95% CI,20.8-82.6) than without immunosuppression (91.3%; 95% CI, 85.6-94.8). Conclusion During March-May 2021, SARS-CoV-2 mRNA vaccines were highly effective for preventing COVID-19 hospitalizations among US adults. SARS-CoV-2 vaccination was beneficial for patients with immunosuppression, but effectiveness was lower in the immunosuppressed population.

引用

页码：1515 / 1524

页数：10

共 50 条

[1] Protection Against Severe Clinical Outcomes With Adenovirus or Messenger RNA Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines in Patients Hospitalized With Coronavirus Disease 2019
Llibre, Josep M.
Revollo, Boris
Aguilar, Sergi
Calomarde-Gomez, Cristina
Bruguera, Andreu
Martin-Iguacel, Raquel
JOURNAL OF INFECTIOUS DISEASES, 2022, 226 (05): : 938 - 940
[2] Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States
Harcourt, Jennifer
Tamin, Azaibi
Lu, Xiaoyan
Kamili, Shifaq
Sakthivel, Senthil K.
Murray, Janna
Queen, Krista
Tao, Ying
Paden, Clinton R.
Zhang, Jing
Li, Yan
Uehara, Anna
Wang, Haibin
Goldsmith, Cynthia
Bullock, Hannah A.
Wang, Lijuan
Whitaker, Brett
Lynch, Brian
Gautam, Rashi
Schindewolf, Craig
Lokugamage, Kumari G.
Scharton, Dionna
Plante, Jessica A.
Mirchandani, Divya
Widen, Steven G.
Narayanan, Krishna
Makino, Shinji
Ksiazek, Thomas G.
Plante, Kenneth S.
Weaver, Scott C.
Lindstrom, Stephen
Tong, Suxiang
Menachery, Vineet D.
Thornburg, Natalie J.
EMERGING INFECTIOUS DISEASES, 2020, 26 (06) : 1266 - 1273
[3] Effectiveness of Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccines Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in a Cohort of Healthcare Personnel
Swift, Melanie D.
Breeher, Laura E.
Tande, Aaron J.
Tommaso, Christopher P.
Hainy, Caitlin M.
Chu, Haitao
Murad, M. Hassan
Berbari, Elie F.
Virk, Abinash
CLINICAL INFECTIOUS DISEASES, 2021, 73 (06) : E1376 - E1379
[4] Differential Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Profiles After Allergic Reactions to Messenger RNA Coronavirus Disease 2019 Vaccine
Maron, Jenny S.
Conroy, Michelle
Naranbai, Vivek
Samarakoon, Upeka
Motazedi, Tina
Farmer, Jocelyn R.
Freeman, Esther
Banerji, Aleena
Bartsch, Yannic C.
Gregory, David J.
Poznansky, Mark C.
Alter, Galit
Blumenthal, Kimberly G.
JOURNAL OF INFECTIOUS DISEASES, 2022, 226 (07): : 1231 - 1236
[5] Severe Acute Respiratory Syndrome Coronavirus 2 Infection History and Antibody Response to 3 Coronavirus Disease 2019 Messenger RNA Vaccine Doses
Herring, Meghan K.
Romine, James K.
Wesley, Meredith G.
Ellingson, Katherine D.
Yoon, Sarang K.
Caban-Martinez, Alberto J.
Meece, Jennifer
Gaglani, Manjusha
Grant, Lauren
Olsho, Lauren E. W.
Tyner, Harmony L.
Naleway, Allison L.
Khan, Sana M.
Phillips, Andrew L.
Solle, Natasha Schaefer
Rose, Spencer
Mak, Josephine
Fuller, Sammantha B.
Hunt, Angela
Kuntz, Jennifer L.
Beitel, Shawn
Yoo, Young M.
Zheng, Pearl Q.
Arani, Gayatri
Lamberte, Julie Mayo
Edwards, Taylor
Thompson, Mark G.
Sprissler, Ryan
Thornburg, Natalie J.
Lowe, Ashley A.
Pilishvili, Tamara
Uhrlaub, Jennifer L.
Lutrick, Karen
Burgess, Jefferey L.
Fowlkes, Ashley L.
CLINICAL INFECTIOUS DISEASES, 2023, 76 (10) : 1822 - 1831
[6] Effectiveness of Messenger RNA-based Vaccines During the Emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant
Sharma, Aditya
Oda, Gina
Holodniy, Mark
CLINICAL INFECTIOUS DISEASES, 2022, 75 (12) : 2186 - 2192
[7] Longitudinal Neutralizing and Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants Following Messenger RNA Coronavirus Disease 2019 Vaccination
Chen, Xuemin
Ciric, Caroline
Gibson, Theda
Anderson, Larry J.
Anderson, Evan J.
Rostad, Christina A.
OPEN FORUM INFECTIOUS DISEASES, 2023, 10 (04):
[8] Coronavirus Disease 2019: Implications of Severe Acute Respiratory Syndrome Coronavirus 2 in Acute Kidney Injury
Alenazi, Abeer Ageel
AlDkhil, Lujain Mohammad Dkhil
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION, 2020, 31 (06) : 1456 - 1457
[9] Viral Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Patients with Coronavirus Disease 2019
Kim, Da Young
Bae, Eun Kyung
Seo, Jun-Won
Yun, Na Ra
Kim, Choon-Mee
Kim, Dong-Min
MICROBIOLOGY SPECTRUM, 2021, 9 (02):
[10] Severe Acute Respiratory Syndrome Coronavirus 2 and Coronavirus Disease 2019: A Clinical Overview and Primer
Knight, Tristan E.
BIOPRESERVATION AND BIOBANKING, 2020, 18 (06) : 492 - 502

← 1 2 3 4 5 →