Anti-apoptotic versus pro-apoptotic signal transduction:: Checkpoints and stop signs along the road to death

被引：142
|
作者：
Jarpe, MB
Widmann, C
Knall, C
Schlesinger, TK
Gibson, S
Yujiri, T
Fanger, GR
Gelfand, EW
Johnson, GL [1 ]
机构：
[1] Natl Jewish Med & Res Ctr, Program Mol Signal Transduct, Div Basic Sci, Denver, CO 80206 USA
[2] Natl Jewish Med & Res Ctr, Dept Pediat, Denver, CO 80206 USA
[3] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA
来源：
ONCOGENE | 1998年 / 17卷 / 11期
关键词：
signal transduction; cell death;
D O I：
10.1038/sj.onc.1202183
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The activation of caspases is a final commitment step for apoptosis. It is now evident that signal transduction pathways involving specific protein kinases modulate the apoptotic response. Both pro-apoptotic and anti-apoptotic pathways integrate environmental cues that control the decision to undergo apoptosis. Pro- and anti-apoptotic signal pathways regulate the activation of the caspases. In this review we describe our current understanding of apoptotic signal transduction.
引用
收藏
页码：1475 / 1482
页数：8
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