Expression of MACC1-1 and c-Met in human prostatic cancer and their clinicopathological significance

Objective: Metastasis-associated in colon cancer-1 (MACC-1) and c-Met are associated with tumorigenesis and progression. The aim of this study is to investigate the expression of MACC-1 and c-Met in human prostatic cancer (PCa) and explore their clinical and pathological significance. Methods: The expression of MACC-1 and c-Met protein were detected in 84 cases of human PCa and 20 cases of benign prostatic hyperplasia (BPH) tissues by the immunohistochemical method. Results: The positive expression level of MACC-1 was 56.0% in human PCa which was higher than that in BPH tissues (20.0%), P=0.004. The overexpression of MACC1 protein was correlated with tumor Gleason score, PSA and TNM stage (P=0.001, P=0.027 and P<0.001, respectively). The positive expression of c-Met was 64.3% in PCa, which was higher than that in BPH tissues (30%). P=0.005. The overexpression of c-Met protein was correlated with tumor Gleason score, PSA and TNM stage (P=0.020, P=0.037 and P<0.001, respectively). The log-rank test statistical analysis suggested that patients with overexpression MACC-1 or c-Met protein had shorter overall survival time, while patients with lower expression MACC-1 or c-Met protein had better survival. Conclusion: Overexpression of MACC-1 and c-Met are markedly correlated with tumor Gleason score, PSA and TNM stage. Detection of MACC-1 and c-Met may be helpful to evaluate prognosis and infiltrative capability of PCa. In PCa tissues, the expression of MACC-1 was positively correlated with the expression of c-Met protein (r=0.540, P<0.001).