2-Methoxy-6-Acetyl-7-Methyljuglone: A Bioactive Phytochemical with Potential Pharmacological Activities

被引：3

作者：

Khalil, Atif Ali Khan ^{[1
]}

Qazi, Asma Saleem ^{[1
]}

Nasir, Abdul ^{[2
]}

Ahn, Mi-Jeong ^{[3
,4
]}

Shah, Muhammad Ajmal ^{[5
]}

Ahmad, Muhammad Saad ^{[1
]}

Sajjad, Wasim ^{[1
]}

Ali, Tahir ^{[6
]}

Naeem, Muhammad ^{[1
]}

Shah, Fawad Ali ^{[7
]}

Khan, Muhammad Tufail Ahmed ^{[8
]}

Romman, Muhammad ^{[9
]}

Rehman, Shahfiq Ur ^{[10
]}

Haider, Adnan ^{[1
]}

Noor, Raishma ^{[11
]}

机构：

[1] Natl Univ Med Sci, Dept Biol Sci, Rawalpindi 46000, Pakistan

[2] Ajou Univ, Dept Mol Sci & Technol, Suwon 16499, South Korea

[3] Gyeongsang Natl Univ, Coll Pharm, Jinju 52828, South Korea

[4] Gyeongsang Natl Univ, Pharmaceut Sci Res Inst, Jinju 52828, South Korea

[5] Univ Faisalabad, Govt Coll, Fac Pharmaceut Sci, Dept Pharmacognosy, Faisalabad 38000, Pakistan

[6] Univ Calgary, Dept Comparat Biol & Expt Med, Fac Vet Med, Hotchkiss Brain Inst,Cumming Sch Med, Calgary, AB T2N 4Z6, Canada

[7] Riphah Int Univ, Riphah Inst Pharmaceut Sci, Islamabad 44000, Pakistan

[8] Agr Univ Peshawar, Dept DVM, Peshawar, Pakistan

[9] Univ Chitral, Dept Bot, Chitral, Pakistan

[10] North West Inst Hlth Sci, Dept Rehabil, Peshawar, Pakistan

[11] Islamia Coll Univ, Dept Chem, Peshawar, Pakistan

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2022年 / 22卷 / 04期

关键词：

2-Methoxy-6-acetyl-7-methyljuglone; antioxidant; anticancer; anti-inflammatory; antibacterial; MAPK; POLYGONUM-CUSPIDATUM; NATURAL-PRODUCTS; CHRONIC INFLAMMATION; NITRIC-OXIDE; CANCER; 2-METHOXYSTYPANDRONE; NECROPTOSIS; INHIBITION; MECHANISMS; DISCOVERY;

D O I：

10.2174/1871520621666210623095636

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Natural products have been the focus of biomedical and pharmaceutical research to develop new therapies in recent years. 2-methoxy-6-acetyl-7-methyljuglone (2-methoxystypandrone, MAM) a natural bioactive juglone derivative, is known to have various levels of pharmacotherapeutic efficacies as an anti-inflammatory, anticancer, antioxidant, antimicrobial, and anti-HIV activities. MAM fights cancer progression by inducing apoptosis, necroptosis and deregulating signaling pathways through H2O2-induced JNK/iNOS/NO and MAPK, ERK1/2 pathways, JNK activation, and the RIP1/RIP3 complex. In this review, we summarize the pharmacological importance of MAM in the field of drug discovery. Furthermore, this review not only emphasizes the medicinal properties of MAM, but also discusses its potential efficacy in future medicinal products.

引用

页码：687 / 693

页数：7

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