Effect of conjugated linoleic acid on bone formation and rheumatoid arthritis

被引：32

作者：

Hur, Sun Jin ^{[1
]}

Park, Yeonhwa ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2007年 / 568卷 / 1-3期

关键词：

conjugated linoleic acid; bone formation; rheumatoid arthritis; anti-inflammatory; cytokine; PPARs;

D O I：

10.1016/j.ejphar.2007.04.056

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Conjugated linolcic acid (CLA) has shown a variety of biologically beneficial effects. Dietary CLA inhibits eddosteal bone resorption, increases endocortical bone formation, and modulates the action and expression of cyclooxygenase (COX) enzyme, thereby decreasing prostaglandin-dependent bone resorption. CLA also enhances calcium absorption and may improve bone formation in animals, although results are not consistent. Since CLA can also affect inflammatory cytokines, it is hypothesized that CLA may be a good tool for prevention or reduction of rheumatoid arthritis symptoms. The possible mechanisms by which CLA prevents rheumatoid arthritis as well as other inflammatory diseases is discussed. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：16 / 24

页数：9

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