GAT107, a Novel Agonistic Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor Restores Hyperoxia-Compromised Macrophage Function

被引:0
|
作者
Gauthier, Alex [1 ]
机构
[1] St Johns Univ, New York, NY USA
关键词
D O I
10.1016/j.freeradbiomed.2016.10.143
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
102
引用
收藏
页码:S55 / S55
页数:1
相关论文
共 50 条
  • [21] Expression of Concern to: The α7 nicotine acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function
    Ravikumar A. Sitapara
    Daniel J. Antoine
    Lokesh Sharma
    Vivek S. Patel
    Charles R. Ashby
    Samir Gorasiya
    Huan Yang
    Michelle Zur
    Lin L. Mantell
    Molecular Medicine, 2020, 26
  • [22] RETRACTION: The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function (Retraction of Vol 20, Pg 238, 2014)
    Sitapara, Ravikumar A.
    Antoine, Daniel J.
    Sharma, Lokesh
    Patel, Vivek S.
    Ashby, Charles R., Jr.
    Gorasiya, Samir
    Yang, Huan
    Zur, Michelle
    Mantell, Lin L.
    MOLECULAR MEDICINE, 2020, 26 (01)
  • [23] Pharmacological Characterization of the Novel and Selective α7 Nicotinic Acetylcholine Receptor-Positive Allosteric Modulator BNC375
    Wang, Xiaohai
    Daley, Christopher
    Gakhar, Vanita
    Lange, Henry S.
    Vardigan, Joshua D.
    Pearson, Michelle
    Zhou, Xiaoping
    Warren, Lee
    Miller, Corin O.
    Belden, Michelle
    Harvey, Andrew J.
    Grishin, Anton A.
    Coles, Carolyn J.
    O'Connor, Susan M.
    Thomson, Fiona
    Duffy, Joseph L.
    Bell, Ian M.
    Uslaner, Jason M.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2020, 373 (02): : 311 - 324
  • [24] Early Process Development and Scale-Up of a Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor
    Tajima, Takayoshi
    Ito, Go
    Saito, Aki
    Kohmura, Yoshinori
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2024, 28 (02) : 500 - 510
  • [25] Alpha-7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator Galantamine in Autism Spectrum Disorder
    Rahman, Asif
    Freedman, Robert
    Hollander, Eric
    BIOLOGICAL PSYCHIATRY, 2018, 83 (09) : S369 - S370
  • [26] NOOTROPIC EFFECTS OF AN α7 NICOTINIC ACETYLCHOLINE RECEPTOR POSITIVE ALLOSTERIC MODULATOR IN CHRONIC TRAUMATIC BRAIN INJURY
    Atkins, Coleen M.
    Johnstone, Timothy
    Hogenkamp, Derk
    Gee, Kelvin
    Titus, David J.
    JOURNAL OF NEUROTRAUMA, 2018, 35 (16) : A183 - A183
  • [27] POSITIVE A7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATOR EFFECTS ON SUSTAINED ATTENTION AND CHOLINERGIC NEUROTRANSMISSION
    Race, Nicholas
    Moschonas, Eleni
    Rennerfeldt, Piper
    Reddy, Rithika
    Ranellone, Tyler
    Balaji, Sruti
    Cheng, Jeffrey
    Carlson, Shaun
    Dixon, C. Edward
    Kline, Anthony
    Bondi, Corina
    JOURNAL OF NEUROTRAUMA, 2021, 38 (14) : A80 - A80
  • [28] IDENTIFICATION AND PHARMACOLOGICAL EVALUATION OF A NOVEL POSITIVE ALLOSTERIC MODULATOR OF ALPHA 7 NICOTINIC RECEPTOR CHANNEL
    Wang, K.
    Tang, J.
    Luo, L.
    Sun, Q.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2014, 115 : 124 - 124
  • [29] The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages
    Gauthier, Alex G.
    Wu, Jiaqi
    Lin, Mosi
    Sitapara, Ravikumar
    Kulkarni, Abhijit
    Thakur, Ganesh A.
    Schmidt, Edward E.
    Perron, Jeanette C.
    Ashby Jr, Charles R.
    Mantell, Lin L.
    ANTIOXIDANTS, 2021, 10 (01) : 1 - 19
  • [30] Characterization of the effects of novel positive allosteric modulators on the functionality of the α7 nicotinic acetylcholine receptor (nAChR)
    Reilly-Andujar, Francis
    Lasalde, Jose A.
    Colon, Jose O.
    FASEB JOURNAL, 2018, 32 (01):