Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species

被引：22
|
作者：
Killday, KB
Yarwood, D
Sills, MA
Murphy, PT
Hooper, JNA
Wright, AE
机构：
[1] Harbor Branch Oceanog Inst Inc, Div Biomed Marine Res, Ft Pierce, FL 34946 USA
[2] Novartis Inst Biomed Res, Summit, NJ 07901 USA
[3] Australian Inst Marine Sci, Townsville, Qld 4810, Australia
[4] Queensland Museum, Brisbane, Qld 4101, Australia
来源：
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 04期
关键词：
D O I：
10.1021/np000546z
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new purine derivative microxine (1) was isolated from the Australian marine sponge Microxina sp. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. Microxine was found to weakly inhibit cdc2 kinase activity with an IC50 of 13 muM.
引用
收藏
页码：525 / 526
页数：2
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