Polyamines in the basal ganglia of human brain.: Influence of aging and degenerative movement disorders

被引：54
|
作者：
Vivó, M
de Vera, N
Cortés, R
Mengod, G
Camón, L
Martínez, E
机构：
[1] CSIC, IDIBAPS, Inst Invest Biomed Barcelona, Dept Neurochem, Barcelona 08036, Spain
[2] CSIC, IDIBAPS, Inst Invest Biomed Barcelona, Dept Pharmacol & Toxicol, Barcelona 08036, Spain
来源：
NEUROSCIENCE LETTERS | 2001年 / 304卷 / 1-2期
关键词：
putrescine; spermidine; spermine; Parkinson's disease; Huntington's disease; progressive supranuclear palsy; basal ganglia; high pressure liquid chromatography;
D O I：
10.1016/S0304-3940(01)01776-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The distribution of polyamines in the human basal ganglia was examined, using dansyl-derivatives and high pressure liquid chromatography with fluorimetric detection. A heterogeneous distribution of putrescine, spermidine (SD) and spermine (SM) was observed in control brains. A consistent negative correlation between SD and SM content and age was found in different brain areas. These results suggest an involvement of polyamines in age-related changes occurring in white-matter, When the influence of degenerative movement disorders -Parkinson's disease, Huntington's disease (HD) and progressive supranuclear palsy-was analyzed, significant changes were observed only in HD, where a decrease in the concentration of SM was found in the putamen. These results suggest that in advanced stages of neurodegenerative processes, polyamines maintain their regulation. Only in the presence of severe atrophy, SM concentration is reduced. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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页码：107 / 111
页数：5
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