Up-regulation of CD44 in rheumatoid chondrocytes

被引：0
|
作者：
Takagi, T [1 ]
Okamoto, R [1 ]
Suzuki, K [1 ]
Hayashi, T [1 ]
Sato, M [1 ]
Sato, M [1 ]
Kurosaka, N [1 ]
Koshino, T [1 ]
机构：
[1] Yokohama City Univ, Sch Med, Dept Orthopaed Surg, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan
来源：
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 2001年 / 30卷 / 02期
关键词：
CD44; rheumatoid arthritis; cartilage;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The adhesion molecule CD44 is thought to play an important role in the inflammatory process. To identify the expression of CD44 in articular chondrocytes in rheumatoid arthritis (RA), monoclonal anti-CD44 antibodies were immunohistochemically used to react with articular cartilage specimens of 15 patients with RA. 9 with osteoarthritis (OA). and h with femoral neck fracture (FF). The proportion of CD44-positive chondrocytes in RA was 93 +/-2% (N = 16). which was significantly higher than that in OA (59 +/- 7%, N = 9, p < 0.001) and FF (46 <plus/minus> 5%, N = 6, p < 0.001). Among CD44 isoforms examined, the hemopoietic form was dominant in chondrocytes in RA. Therefore, up-regulation of CD44 on chondrocytes may play a significant role in cartilage degeneration in RA.
引用
收藏
页码：110 / 113
页数：4
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