Condensed bridgehead nitrogen heterocyclic systems:: synthesis, bioactivity and stereochemistry of pyrazolo [3′,4′:4,5] thiazolo [3,2-b]-s-triazoles

被引：0

作者：

Mohan, J ^{[1
]}

Kumar, A ^{[1
]}

Kumar, P ^{[1
]}

机构：

[1] Maharshi Dayanand Univ, Dept Chem, Rohtak 124001, Haryana, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2003年 / 12卷 / 04期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile synthesis of 2,3-diaryl-6-nitrophenyl-cis-3,3a-dihydropyrazolo [3',4':4,5] thiazolo [3,2-b]-s-triazoles 3 has been achieved by the condensation of 3-p-nitrophenyl-s-triazole-5-thione 1 with chloroacetic acid and aldehydes in the presence of acetic anhydride, anhyd sodium acetate and gl acetic acid to yield 2-p-nitrophenyl-6-arylidene thiazolo [3,2-b]-s-triazolo-5(6H)-one 2 followed by treatment with 2,4-dinitrophenylhydrazine. The structures 3 were supported by IR and H-1 NMR spectral data. The appearance of two doublets (J=8.2 Hz) at delta 8.35 and 8.86 corroborated the cyclic structure and cis configuration. The antibacterial and antifungal activities of the system have also been evaluated.

引用

页码：375 / 376

页数：2

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