Role of the multifunctional transcription factor TFII-I in DNA damage repair

被引：7
|
作者：
Roy, Ananda L. [1 ]
机构：
[1] Natl Inst Hlth, Natl Inst Aging, Biomed Res Ctr, Lab Mol Biol & Immunol, Baltimore, MD 21224 USA
来源：
DNA REPAIR | 2021年 / 106卷
基金：
美国国家卫生研究院;
关键词：
Gene expression; Transcription factor; TFII-I; DNA damage; DNA repair; CELL-CYCLE; BINDING-PROTEIN; PROMOTER ACTIVITY; GENE; GENOME; ACTIVATOR; BAP-135; TARGET; GTF2I;
D O I：
10.1016/j.dnarep.2021.103175
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The multifunctional transcription factor TFII-I, encoded by the GTF2I gene, is implicated in various biological pathways, and associated with multiple human disorders. Evidence is also mounting to suggest that TFII-I is involved in DNA damage repair pathways. Here I bring together these recent observations and suggest a connection between transcriptional and DNA repair functions of TFII-I.
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页数：4
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