Roles of Mifepristone on the Regulation of Cytotoxic Lymphocytes and Regulatory T Cells

被引：3
|
作者：
Liu, Linxiang [1 ]
Zhou, Feng [2 ]
Qin, Jiale [3 ]
Qian, Zhida [4 ]
Huang, Lili [4 ]
机构：
[1] Zhejiang Univ, Dept Obstet & Gynecol, Zhejiang Univ Hosp, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Dept Pathol, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Univ, Dept Ultrasound, Hangzhou, Zhejiang, Peoples R China
[4] Zhejiang Univ, Dept Obstet & Gynecol, Womens Hosp, Sch Med, Hangzhou, Zhejiang, Peoples R China
来源：
GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2017年 / 82卷 / 06期
关键词：
Mifepristone; Regulatory T cells; Cytotoxic lymphocytes; Cytotoxic T cells; CD56+natural killer cells; NATURAL-KILLER-CELLS; SPONTANEOUS-ABORTION; RECURRENT MISCARRIAGE; PERIPHERAL-BLOOD; PREGNANCY; WOMEN; ENDOMETRIUM; NK;
D O I：
10.1159/000455848
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To investigate the immunologic function of mifepristone, which acts as a contraceptive drug at the level of the decidua. Setting: In our hospital, 60 women (less than 63 days of amenorrhea) volunteered to terminate their pregnancies by the uterine suction evacuation method. Immunohistochemically, the transcription factor forkhead box P3 and granzyme B staining were performed to identify regulatory T cells and cytotoxic lymphocytes (CLs) in all operational subjects. CD8 (cytotoxic T cells marker) and CD56 (natural killer cells marker) staining were further performed in order to characterize the CLs subpopulations. Result: A significantly increased number of CLs was found in the decidua treated with mifepristone. Conclusion: Mifepristone increases the expression of CLs in the decidua, and it provides new insights into the immunologic function of mifepristone as a drug used for pregnancy termination. (C) 2017 S. Karger AG, Basel
引用
收藏
页码：533 / 537
页数：5
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