Biomaterial microarrays: rapid, microscale screening of polymer-cell interaction

被引：201
|
作者：
Anderson, DG
Putnam, D
Lavik, EB
Mahmood, TA
Langer, R
机构：
[1] MIT, Dept Chem Engn, Div Biol Engn, Cambridge, MA 02139 USA
[2] Cornell Univ, Sch Chem & Biomol Engn, Dept Biomed Engn, Ithaca, NY USA
[3] Yale Univ, Dept Biomed Engn, New Haven, CT 06520 USA
来源：
BIOMATERIALS | 2005年 / 26卷 / 23期
关键词：
microarray; biomaterials; PLGA;
D O I：
10.1016/j.biomaterials.2004.11.052
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The identification of biomaterials that induce optimal gene expression patterns and allow for appropriate levels of cellular attachment is of central importance in tissue engineering and cell therapy. Herein, we describe the creation of cell-compatible, biomaterial microarrays, that allow rapid, microscale testing of biomaterial interactions with cells. As proof of principle, we simultaneously characterized over 3456 human mesenchymal stem cell (hMSC)-biomaterial composite interactions, and describe preliminary studies on the utility of these arrays with a neural stem cell line (NSC), and primary articular chondrocytes. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4892 / 4897
页数：6
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