Hypervalent iodine(III)-mediated C(sp3)-H bond arylation, alkylation, and amidation of isothiochroman

被引：11
|
作者：
Muramatsu, Wataru [1 ]
Nakano, Kimihiro [1 ]
机构：
[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 02期
关键词：
Isothiochroman; C-H activation; Hypervalent iodine; Arylation; Alkylation; Amidation; THIOBENZOPHENONE; CHEMISTRY; OXIDATION; TETRAHYDROISOQUINOLINES;
D O I：
10.1016/j.tetlet.2014.11.134
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed a one-step method for introducing aryl, alkyl, and amide groups at the C(1)-position of isothiochromans via an oxidation reaction using hypervalent iodine(III), [bis(trifluoroacetoxy) iodo]benzene (PIFA), followed by an nucleophilic addition reaction using Grignard reagents and an amide. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：437 / 440
页数：4
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