user

The Oxidation of Amides to Imides: A Powerful Synthetic Transformation

被引：36
|
作者：
Sperry, Jonathan [1 ]
机构：
[1] Univ Auckland, Sch Chem Sci, Auckland 1, New Zealand
来源：
SYNTHESIS-STUTTGART | 2011年 / 22期
关键词：
imide; amide; oxidation; organic synthesis; RUTHENIUM TETROXIDE OXIDATION; ALPHA-AMINO-ACIDS; 1,3-DIPOLAR CYCLOADDITION REACTION; SUBSTITUTED CYCLIC IMIDES; FLUORESCENS DSM 11579; N-ACYL-PYRROLIDINES; STEREOSPECIFIC SYNTHESIS; BIOLOGICAL-ACTIVITY; AEROBIC PHOTOOXIDATION; ASYMMETRIC-SYNTHESIS;
D O I：
10.1055/s-0030-1260237
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Despite appearing to be a conceptually simple transformation, the oxidation of amides to imides is far from straightforward, primarily due to the inertness of amides toward electrophilic oxidants. This perspective provides an overview of the development of reaction conditions capable of effecting this oxidation. The application of amide to imide oxidations in the fields of medicinal chemistry and natural product synthesis, as well as the advantages and limitations of the various oxidation conditions, is also discussed.
引用
收藏
页码：3569 / 3580
页数：12
相关论文
共 50 条
12345