Profiling of Specific Gene Expression Pathways in Peripheral Cells from Prodromal Alzheimer's Disease Patients

被引:3
|
作者
Serpente, Maria [1 ]
Fenoglio, Chiara [1 ]
Cioffi, Sara Maria Giulia [1 ]
Oldoni, Emanuela [1 ]
Arcaro, Marina [1 ]
Arighi, Andrea [1 ]
Fumagalli, Giorgio Giulio [1 ,2 ]
Ghezzi, Laura [1 ]
Scarpini, Elio [1 ]
Galimberti, Daniela [1 ]
机构
[1] Univ Milan, Osped Maggiore Policlin, Fdn Ca Granda,Neurodegenerat Dis Unit,IRCCS, Dino Ferrari Ctr,Dept Pathophysiol & Transplantat, Milan, Italy
[2] Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, Florence, Italy
关键词
Gene expression; insulin; insulin receptor; peripheral biomarkers; prodromal Alzheimer's disease; FRONTOTEMPORAL DEMENTIA; COGNITIVE IMPAIRMENT; INSULIN; BRAIN; DIAGNOSIS;
D O I
10.3233/JAD-170861
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Herein, we performed a gene expression profiling in a cohort of 10 mild cognitive impairment (MCI), subdivided, according to the analysis of cerebrospinal fluid biomarkers, in prodromal Alzheimer's disease (AD) and non-AD MCI, as compared with 27 AD patients and 24 controls, in order to detect early gene expression alterations. We observed a significant upregulation of insulin (INS) and INS Receptor (INSR) expression levels in AD both prodromal and fully symptomatic, as compared with controls, but not in MCI subjects. Our results suggest an early dysregulation of INS and INSR in AD pathogenesis and pave the way to a possible utility of these transcripts as peripheral biomarkers.
引用
收藏
页码:1289 / 1294
页数:6
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