MicroRNAs Regulate Bone Development and Regeneration

被引：100
|
作者：
Fang, Sijie [1 ]
Deng, Yuan [1 ]
Gu, Ping [1 ]
Fan, Xianqun [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Dept Ophthalmol, Shanghai Peoples Hosp 9, Sch Med, Shanghai 200011, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 04期
基金：
中国国家自然科学基金;
关键词：
microRNA; osteogenesis; bone regeneration; MESENCHYMAL STEM-CELLS; SUPPRESSES OSTEOGENIC DIFFERENTIATION; HUMAN ADIPOSE-TISSUE; OSTEOBLAST DIFFERENTIATION; TRANSCRIPTION FACTOR; TARGETING OSTERIX; LINEAGE PROGRESSION; PARATHYROID-HORMONE; SIGNALING PATHWAY; ALAGILLE SYNDROME;
D O I：
10.3390/ijms16048227
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNAs (miRNAs) are endogenous small noncoding similar to 22-nt RNAs, which have been reported to play a crucial role in maintaining bone development and metabolism. Osteogenesis originates from mesenchymal stem cells (MSCs) differentiating into mature osteoblasts and each period of bone formation is inseparable from the delicate regulation of various miRNAs. Of note, apprehending the sophisticated circuit between miRNAs and osteogenic homeostasis is of great value for artificial skeletal regeneration for severe bone defects. In this review, we highlight how different miRNAs interact with diverse osteo-related genes and endeavor to sketch the contours of potential manipulations of miRNA-modulated bone repair.
引用
收藏
页码：8227 / 8253
页数：27
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