Impairment on sperm quality and fertility of adult rats after antiandrogen exposure during prepuberty

被引：43
|
作者：
Perobelli, Juliana Elaine [1 ,2 ]
Alves, Thais Regina [1 ]
de Toledo, Fabiola Choqueta [1 ]
Fernandez, Carla Dal Bianco [1 ,2 ]
Anselmo-Franci, Janete A. [3 ]
Klinefelter, Gary R.
Kempinas, Wilma De Grava [1 ]
机构：
[1] Univ Estadual Paulista, UNESP, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP, Brazil
[2] Univ Estadual Campinas, UNICAMP, Inst Biol, Grad Program Cellular & Struct Biol, Campinas, SP, Brazil
[3] Univ Sao Paulo, Sch Dent, Dept Morphol Stomatol & Physiol, BR-14049 Ribeirao Preto, SP, Brazil
来源：
REPRODUCTIVE TOXICOLOGY | 2012年 / 33卷 / 03期
基金：
巴西圣保罗研究基金会;
关键词：
Antiandrogen; Rat; Epididymis; Prepuberty; Sperm quality; Fertility; Proteomics; EPIDIDYMAL SPERM; REPRODUCTIVE DEVELOPMENT; SEXUAL-BEHAVIOR; ENVIRONMENTAL ANTIANDROGENS; ANDROGEN RECEPTOR; CANCER CELLS; PROTEINS; TRANSIT; MATURATION; SINGLE;
D O I：
10.1016/j.reprotox.2011.12.011
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
This study evaluated the effects of antiandrogen exposure during the prepubertal period on reproductive development and reproductive competence in adults. Male rats were divided into two groups: flutamide, receiving 25 mg/kg/day of flutamide by oral gavage and control, receiving vehicle daily. Dosing continued from PND 21 to 44, and animals were killed on PND 50 or PND 75-80. The epididymis, prostate, vas deferens and seminal vesicle weights were lower in Flutamide group on PND 50, while on PND 80 only seminal vesicle weight was reduced. Fertility assessed by IUI revealed a decrease in the fertility potential in the flutamide-treated adults. Flutamide accelerated sperm transit time through the epididymis, impairing sperm motility and storage. A quantitative analysis of the cauda sperm membrane proteome revealed a few significant changes in protein expression. Thus, exposure to flutamide during the prepubertal period compromises the function of the epididymis along with epididymal sperm quality at adulthood. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：308 / 315
页数：8
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