Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1

被引：11
|
作者：
Sun, Wanpeng [1 ]
Qiao, Ling [2 ]
Liu, Qiang [2 ]
Chen, Lifeng [1 ]
Ling, Binbing [1 ]
Sammynaiken, Ramaswami [3 ]
Yang, Jian [1 ]
机构：
[1] Univ Saskatchewan, Drug Design & Discovery Res Grp, Coll Pharm & Nutr, Saskatoon, SK S7N 5C9, Canada
[2] Univ Saskatchewan, Vaccine & Infect Dis Org, Saskatoon, SK S7N 5E3, Canada
[3] Univ Saskatchewan, Saskatchewan Struct Sci Ctr, Saskatoon, SK S7N 5C9, Canada
来源：
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2011年 / 8卷 / 02期
关键词：
RIZ1; RIZ; Human tumor suppressor; tumor metastasis; ZINC-FINGER GENE; GROWTH-FACTOR; BREAST-CANCER; EXPRESSION; BINDING; OVEREXPRESSION; RECEPTOR; HYPERMETHYLATION; METASTASIS; MECHANISM;
D O I：
10.7150/ijms.8.161
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Human tumor suppressor gene RIZ encodes two protein products, tumor suppressor RIZ1 and proto-oncoprotein RIZ2, which regulate cellular functions in a Yin-Yang fashion. The only structural difference between them is that RIZ2 lacks the N-terminal PR domain. In this study, we showed that RIZ1 mRNA expression level was elevated in stage IV of eight different types of cancer (stage III for prostate cancer), indicating that RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity.
引用
收藏
页码：161 / 167
页数：7
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