Alpha-fetoprotein (AFP)- and des-gamma-carboxy prothrombin (DCP)-producing adenocarcinoma of the stomach with liver metastasis in a patient with chronic hepatitis C

被引：7
|
作者：
Sohda, T
Tomioka, Y
Inomata, S
Morita, I
Eguchi, K
Aoyagi, K
Watanabe, H
Nakamura, S
Sakisaka, S
机构：
[1] Fukuoka Univ, Sch Med, Dept Med 3, Jonan Ku, Fukuoka 8140180, Japan
[2] Nakamura Gastrointestinal Clin, Fukuoka, Japan
来源：
INTERNAL MEDICINE | 2005年 / 44卷 / 04期
关键词：
alpha-fetoprotein (AFP); AFP mRNA; des-gamma-carboxy prothrombin (DCP); gastric cancer; hepatitis C virus (HCV); immunohistochemistry;
D O I：
10.2169/internalmedicine.44.294
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 45-year-old man was admitted to our hospital because of chronic hepatitis C and a large liver tumor accompanied by increased serum levels of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP), the tumor markers for hepatocellular carcinoma. Endoscopic examination revealed advanced gastric cancer. Biopsy specimens of the stomach and liver showed gastric adenocarcinoma and its metastasis to the liver. Immunohistochemical studies demonstrated that adenocarcinoma cells both of the stomach and liver, were positive for the antibodies against AFP as well as DCP. Expression of AFP mRNA was shown in the cancer cells of the stomach. Accordingly, we diagnosed this patient with AFP- and DCP-producing adenocarcinoma of the stomach together with liver metastasis.
引用
收藏
页码：294 / 298
页数：5
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