Microarray-Based Technology for Glycomics Analysis

被引：9

作者：

Gao, Jingqing ^{[1
,2
]}

Ma, Lina ^{[1
]}

Liu, Dianjun ^{[1
]}

Wang, Zhenxin ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Electroanalyt Chem, Changchun Inst Appl Chem, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2012年 / 15卷 / 01期

关键词：

Disease diagnosis; glycan; glycomics; high throughput analysis; lectin; living cell; microarray; SURFACE-PLASMON RESONANCE; PROTEIN-CARBOHYDRATE INTERACTIONS; SELF-ASSEMBLED MONOLAYERS; HIGH-THROUGHPUT ANALYSIS; COATED GLASS SLIDES; LECTIN MICROARRAY; GLYCAN MICROARRAYS; QUANTITATIVE-ANALYSIS; NANOPARTICLE PROBES; BACILLUS-ANTHRACIS;

D O I：

10.2174/138620712798280808

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In the post-genomic era, glycomics (the functional study of carbohydrates in living organisms) has come into the forefront of biological research because the interactions of glycoconjugates with proteins not only occur widely in biological processes of cells but also initiate infection of host cells by bacteria and viruses. Microarrays have been reportedly successful in carbohydrate-protein interaction as well as cellular surface glycan profiling. This review provides an overview of recent progress in the development of microarray-based techniques for glycomic studies. The fabrication, application and challenge/bottleneck of glycan/lectin microarrays have been summarized and discussed.

引用

页码：90 / 99

页数：10

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