Genetic and molecular characterization of uveal melanoma cell lines

被引：107

作者：

Griewank, K. G. ^{[2
]}

Yu, X. ^{[1
,3
]}

Khalili, J. ^{[1
,3
]}

Sozen, M. M. ^{[2
]}

Stempke-Hale, K. ^{[3
]}

Bernatchez, C. ^{[1
]}

Wardell, S. ^{[1
]}

Bastian, B. C. ^{[4
]}

Woodman, S. E. ^{[1
,3
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX 77030 USA

[2] Mem Sloan Kettering Comprehens Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA

[4] Univ Calif San Francisco, Dept Dermatol & Pathol, Ctr Comprehens Canc, San Francisco, CA 94143 USA

来源：

PIGMENT CELL & MELANOMA RESEARCH | 2012年 / 25卷 / 02期

关键词：

uveal melanoma; GNAQ; GNA11; BRAF GENE; B-RAF; MUTATIONS; PATHWAY; AKT; ESTABLISHMENT; ACTIVATION; EXPRESSION; SURVIVAL; 3-KINASE;

D O I：

10.1111/j.1755-148X.2012.00971.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal melanoma provides an opportunity to better understand the pathogenesis of this melanoma subtype and to develop rational therapeutics to target the cellular effects mediated by these mutations. Cell lines from uveal melanoma tumors are an essential tool for these types of analyses. We report the mutation status of relevant melanoma genes, expression levels of proteins of interest, and DNA fingerprinting of a panel of uveal melanoma cell lines used in the research community.

引用

页数：7

共 50 条

[31] The genetic basis of uveal melanoma
Nielsen, M.
Dogrusoz, M.
Bleeker, J. C.
Kroes, W. G.
van Asperen, C. A.
Marinkovic, M.
Luyten, G. P. M.
Jager, M. J.
JOURNAL FRANCAIS D OPHTALMOLOGIE, 2015, 38 (06): : 516 - 521
[32] Molecular and pharmacological characterization of mutant NRAS dependency in melanoma cell lines
Mehta, Anita K.
Hua, Kevin
Gadrey, Jayant
Fuller, Angelina
Singh, Anurag
CANCER RESEARCH, 2019, 79 (13)
[33] Molecular Characterization of Human Cutaneous Melanoma-derived Cell Lines
Ogbah, Zighereda
Anton Puig-Butille, Joan
Simonetta, Federico
Badenas, Celia
Cervera, Remedios
Mila, Jordi
Benitez, Daniel
Malvehy, Josep
Vilella, Ramon
Puig, Susana
ANTICANCER RESEARCH, 2012, 32 (04) : 1245 - 1251
[34] Genetic prognostication in uveal melanoma
Dogrusoz, Mehmet
Jager, Martine J.
ACTA OPHTHALMOLOGICA, 2018, 96 (04) : 331 - 347
[35] Genetic determinants of uveal melanoma
Kaur, Jasbir
Malik, Manzoor Ahmad
Gulati, Rishabh
Azad, Shorya Vardhan
Goswami, Sandeep
TUMOR BIOLOGY, 2014, 35 (12) : 11711 - 11717
[36] Genetic alterations in uveal melanoma
Griewank, Klaus G.
Murali, Rajmohan
Wiesner, Thomas
Bastian, Boris C.
EXPERT REVIEW OF OPHTHALMOLOGY, 2011, 6 (02) : 129 - 132
[37] Genetic advances in uveal melanoma
Sisley, Karen
JOURNAL OF MEDICAL GENETICS, 2007, 44 : S42 - S42
[38] New established melanoma cell lines: genetic and biochemical characterization of cell division cycle
Vozza, A
Borriello, A
Criniti, V
Vozza, G
Della Ragione, F
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2003, 17 (01) : 37 - 41
[39] Uveal melanoma cell lines depend on multiple signaling pathways for survival
Park, J. J.
Stewart, A.
Irvine, M.
Pedersen, B.
Kefford, R.
Diefenbach, R.
Carlino, M. S.
Rizos, H.
ANNALS OF ONCOLOGY, 2019, 30
[40] Metastatic behaviour of human uveal melanoma cell lines in a rabbit model
Lewandowski, E
Blanco, PL
Caissie, AL
Morilla-Grasa, A
Cools-Lartigue, JJ
Burnier, MN
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 : U367 - U367

← 1 2 3 4 5 →