Genetic and molecular characterization of uveal melanoma cell lines

被引：107
|
作者：
Griewank, K. G. [2 ]
Yu, X. [1 ,3 ]
Khalili, J. [1 ,3 ]
Sozen, M. M. [2 ]
Stempke-Hale, K. [3 ]
Bernatchez, C. [1 ]
Wardell, S. [1 ]
Bastian, B. C. [4 ]
Woodman, S. E. [1 ,3 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX 77030 USA
[2] Mem Sloan Kettering Comprehens Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA
[4] Univ Calif San Francisco, Dept Dermatol & Pathol, Ctr Comprehens Canc, San Francisco, CA 94143 USA
来源：
PIGMENT CELL & MELANOMA RESEARCH | 2012年 / 25卷 / 02期
关键词：
uveal melanoma; GNAQ; GNA11; BRAF GENE; B-RAF; MUTATIONS; PATHWAY; AKT; ESTABLISHMENT; ACTIVATION; EXPRESSION; SURVIVAL; 3-KINASE;
D O I：
10.1111/j.1755-148X.2012.00971.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal melanoma provides an opportunity to better understand the pathogenesis of this melanoma subtype and to develop rational therapeutics to target the cellular effects mediated by these mutations. Cell lines from uveal melanoma tumors are an essential tool for these types of analyses. We report the mutation status of relevant melanoma genes, expression levels of proteins of interest, and DNA fingerprinting of a panel of uveal melanoma cell lines used in the research community.
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页数：7
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