Malabaricone C from Myristica cinnamomea Exhibits Anti-Quorum Sensing Activity

被引：114

作者：

Chong, Yee Meng ^{[1
]}

Yin, Wai Fong ^{[1
]}

Ho, Chia Yong ^{[1
]}

Mustafa, Mohamad Rais ^{[2
]}

Hadi, A. Hamid A. ^{[2
]}

Awang, Khalijah ^{[2
]}

Narrima, Putri ^{[2
]}

Koh, Chong-Lek ^{[3
]}

Appleton, David R. ^{[2
,4
]}

Chan, Kok-Gan ^{[1
]}

机构：

[1] Univ Malaya, Inst Biol Sci, Div Genet & Mol Biol, Fac Sci, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Dept Pharmacol, Fac Med, Ctr Nat Prod Res & Drug Dev, Kuala Lumpur 50603, Malaysia

[3] Nanyang Technol Univ, Natl Inst Educ, Nat Sci & Sci Educ AG, Singapore 637616, Singapore

[4] Univ Putra Malaysia, UPM MTDC Technol Ctr 3, Sime Darby Technol Ctr Sdn Bhd, Serdang 43400, Selangor, Malaysia

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 10期

关键词：

GENE-EXPRESSION; SIGNAL; INHIBITION; BACTERIA; PLANTS;

D O I：

10.1021/np100872k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further.

引用

页码：2261 / 2264

页数：4

共 50 条

[41] Evaluation of anti-quorum sensing activity of Elaeagnus angustifolia L. extracts from Central Anatolia
Erdonmez, Demet
Kenar, Nihal
Turkmen, Kubra Erkan
JOURNAL OF BIOTECHNOLOGY, 2016, 231 : S34 - S34
[42] Identification and Characterization of Polyphenols from Carissa spinarum Fruit and Evaluation of Their Antioxidant and Anti-quorum Sensing Activity
Maria Sheeba Nazareth
S. V. Shreelakshmi
Nandini P. Shetty
Current Microbiology, 2021, 78 : 1277 - 1285
[43] Anti-quorum sensing activity of some marine bacteria isolated from different marine resources in Egypt
El-Kurdi, Najat
Abdulla, Hesham
Hanora, Amro
BIOTECHNOLOGY LETTERS, 2021, 43 (02) : 455 - 468
[44] Anti-quorum sensing and biofilm inhibitory activity of Apium graveolens L. oleoresin
Nagar, Nupur
Aswathanarayan, Jamuna Bai
Vittal, Ravishankar Rai
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 2020, 57 (07): : 2414 - 2422
[45] Inhibition of quorum sensing by partially purified anti-quorum sensing compound from the marine epibiotic bacteria in Chromobacterium violaceum
Siddhi, Shah
Harsh, Patel
Bhakti, Bajpai
RESEARCH JOURNAL OF BIOTECHNOLOGY, 2023, 18 (09): : 11 - 17
[46] Evaluation of anti-quorum sensing activity of indigenous dietary plants against Pseudomonas aeruginosa
Alva, Prathiksha Prabhakara
Suresh, Sarika
Gururaj, M. P.
Premanath, Ramya
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE, 2019, 30
[47] Anti-quorum sensing and biofilm inhibitory activity of Apium graveolens L. oleoresin
Nupur Nagar
Jamuna Bai Aswathanarayan
Ravishankar Rai Vittal
Journal of Food Science and Technology, 2020, 57 : 2414 - 2422
[48] Identification and Characterization of Polyphenols from Carissa spinarum Fruit and Evaluation of Their Antioxidant and Anti-quorum Sensing Activity
Nazareth, Maria Sheeba
Shreelakshmi, S. V.
Shetty, Nandini P.
CURRENT MICROBIOLOGY, 2021, 78 (04) : 1277 - 1285
[49] Anti-quorum sensing activity of some marine bacteria isolated from different marine resources in Egypt
Najat El-Kurdi
Hesham Abdulla
Amro Hanora
Biotechnology Letters, 2021, 43 : 455 - 468
[50] Anti-quorum sensing activity of selected sponge extracts: a case study of Pseudomonas aeruginosa
Pejin, Boris
Talevska, Aleksandra
Ciric, Ana
Glamoclija, Jasmina
Nikolic, Milos
Talevski, Trajce
Sokovic, Marina
NATURAL PRODUCT RESEARCH, 2014, 28 (24) : 2330 - 2333

← 1 2 3 4 5 →