Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy

被引：33

作者：

Paciaroni, Nicholas G. ^{[1
]}

Ndungu, John M. ^{[1
]}

Kodadek, Thomas ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, 130 Scripps Way, Jupiter, FL 33458 USA

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 34期

基金：

美国国家卫生研究院;

关键词：

ORGANIC-SYNTHESIS; DOUBLE-BONDS; SELECTION; KETONES; GENERATION; OXIDATION; ALKYNES; DESIGN;

D O I：

10.1039/d0cc01474e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.

引用

页码：4656 / 4659

页数：4

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