A chemical synthesis of nicotinamide adenine dinucleotide (NAD+)

被引:67
|
作者
Lee, J [1 ]
Churchil, H [1 ]
Choi, WB [1 ]
Lynch, JE [1 ]
Roberts, FE [1 ]
Volante, RP [1 ]
Reider, PJ [1 ]
机构
[1] Merck Res Labs, Proc Res, Rahway, NJ 07065 USA
关键词
D O I
10.1039/a809930h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A practical synthesis of nicotinamide mononucleotide (beta-NMN) and a high yield coupling with AMP-morpholidate that also provides NAD(+) in an efficient manner are reported.
引用
收藏
页码:729 / 730
页数:2
相关论文
共 50 条
  • [21] COMPARATIVE ADSORPTION OF ADENINE AND NICOTINAMIDE ADENINE-DINUCLEOTIDE (NAD+) AT AN AQUEOUS-SOLUTION MERCURY INTERFACE
    JENSEN, MA
    BRESNAHAN, WT
    ELVING, PJ
    BIOELECTROCHEMISTRY AND BIOENERGETICS, 1983, 11 (4-6): : 299 - 306
  • [22] Regulation of innate immune cell differentiation by mitochondrial nicotinamide adenine dinucleotide (NAD+) levels
    Oliva, Aurea
    Rincon, Ruben
    Traba, Javier
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2024, 1865 : 133 - 133
  • [23] Release, neuronal effects and removal of extracellular β-nicotinamide adenine dinucleotide (β-NAD+) in the rat brain
    Durnin, Leonie
    Dai, Yanping
    Aiba, Isamu
    Shuttleworth, C. William
    Yamboliev, Ilia A.
    Mutafova-Yambolieva, Violeta N.
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2012, 35 (03) : 423 - 435
  • [24] Experimental and theoretical electron density studies in large molecules:: NAD+, β-nicotinamide adenine dinucleotide
    Guillot, B
    Muzet, N
    Artacho, E
    Lecomte, C
    Jelsch, C
    JOURNAL OF PHYSICAL CHEMISTRY B, 2003, 107 (34): : 9109 - 9121
  • [25] Therapeutic potential of nicotinamide adenine dinucleotide (NAD)
    Arenas-Jal, Marta
    Sune-Negre, J. M.
    Garcia-Montoya, Encarna
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2020, 879
  • [26] β-Nicotinamide Adenine Dinucleotide (β-Nad): A New Bronchodilator
    Jurastow, I. G.
    Schlenz, H.
    Krasteva-Christ, G.
    Kummer, W.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187
  • [27] Synthesis of Novel Nicotinamide Adenine Dinucleotide (NAD) Analogs and Their Coenzyme Activities
    Hou, Shuhua
    Liu, Wujun
    Zhao, Zongbao
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2012, 32 (02) : 349 - 353
  • [28] Ex Vivo Lung Perfusion with β-Nicotinamide Adenine Dinucleotide (NAD+) Improves Ischemic Lung Function
    Ehrsam, Jonas Peter
    Chen, Jin
    Biefer, Hector Rodriguez Cetina
    Opitz, Isabelle
    Arni, Stephan
    Inci, Ilhan
    ANTIOXIDANTS, 2022, 11 (05)
  • [29] RADIATION-PRODUCED TRANSIENT RADICAL DERIVED FROM AQUEOUS NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD+)
    LAND, EJ
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE, 1966, 10 (03): : 302 - &
  • [30] EPR and potentiometric studies of copper(II) binding to nicotinamide adenine dinucleotide (NAD+) in water solution
    Hoffmann, Stanislaw K.
    Goslar, Janina
    Lijewski, Stefan
    Basinski, Kamil
    Gasowska, Anna
    Lomozik, Lechoslaw
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2012, 111 : 18 - 24