Hyperthermia with magnetic nanowires for inactivating living cells

被引：52

作者：

Choi, D. S. ^{[1
]}

Park, J. ^{[2
]}

Kim, S. ^{[2
]}

Gracias, D. H. ^{[2
]}

Cho, M. K. ^{[3
]}

Kim, Y. K. ^{[3
]}

Fung, A. ^{[4
]}

Lee, S. E. ^{[5
]}

Chen, Y. ^{[4
]}

Khanal, S. ^{[1
]}

Baral, S. ^{[1
]}

Kim, J. -H. ^{[1
]}

机构：

[1] Univ Idaho, Dept Mat Sci & Engn, Moscow, ID 83844 USA

[2] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

[3] Korea Univ, Dept Mat Sci & Engn, Seoul 136713, South Korea

[4] Univ Calif Los Angeles, Dept Biomed Engn, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Dept Mech & Aerosp Engn, Los Angeles, CA 90095 USA

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2008年 / 8卷 / 05期

关键词：

nanowire; hyperthermia; treatment of cancer; RF heating;

D O I：

10.1166/jnn.2008.273

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe a method to induce hyperthermia in cells, in-vitro, by remotely heating Ni nanowires (NWs) with radio frequency (RF) electromagnetic fields. Ni NWs were internalized by human embryonic kidney cells (HEK-293). Only cells proximal to NWs or with internalized NWs changed shape on exposure to RF fields indicative of cell death. The cell death occurs as a result of hyperthermia, since the RF field remotely heats the NWs as a result of magnetic hysteresis. This is the first demonstration of hyperthermia induced by NWs; since the NWs have anisotropic and strong magnetic moments, our experiments suggest the possibility of performing hyperthermia at lower field strengths in order to minimize damage to untargeted cells in applications such as the treatment of cancer.

引用

页码：2323 / 2327

页数：5

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