An overlooked tumor promoting immunoregulation by non-hematopoietic stromal cells

被引：5
|
作者：
Bose, Anamika [1 ]
Ghosh, Tithi [1 ]
Baral, Rathindranath [1 ]
机构：
[1] CNCI, Dept Immunoregulat & Immunodiagnost, 37 SP Mukherjee Rd, Kolkata 700026, India
来源：
IMMUNOLOGY LETTERS | 2016年 / 176卷
关键词：
Non-hematopoietic stromal cells; Tumor microenvironment; Immunoregulation; Pericytes; Fibroblasts; MESENCHYMAL STEM-CELLS; CANCER-ASSOCIATED FIBROBLASTS; LYMPHATIC ENDOTHELIAL-CELLS; T-CELL; IMMUNE MODULATION; NK CELL; ACTIVATION; PERICYTES; MICROENVIRONMENT; ADIPOCYTES;
D O I：
10.1016/j.imlet.2016.06.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Multidirectional complex communication between tumor-residing hematopoietic and non-hematopoietic stromal cells (NHSCs) decisively regulates cancer development, progression and therapeutic responses. HSCs predominantly participate in the immune regulations, while, NHSCs, provide parenchymal support or serve as a conduit for other cells or support angiogenesis. However, recent reports suggest NHSCs can additionally participate in ongoing tumor promoting immune reactions within tumor-microenvironment (TME). In this review, based on the state-of-art knowledge and accumulated evidence by us, we discuss the role of quite a few NHSCs in tumor from immunological perspectives. Understanding such consequence of NHSCs will surely pave the way in crafting effective cancer management. (C) 2016 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：114 / 121
页数：8
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