The Immune System in Neuroendocrine Tumors

被引：2

作者：

Thiel, A. ^{[1
]}

Ehlers, M. ^{[1
]}

Anlauf, M. ^{[2
]}

Raffel, A. ^{[3
]}

Stoecklein, N. H. ^{[3
]}

Schott, M. ^{[1
]}

机构：

[1] Univ Hosp Dusseldorf, Dept Endocrinol Diabetol & Rheumatol, D-40225 Dusseldorf, Germany

[2] Univ Hosp Dusseldorf, Inst Pathol & Endocrine Tumor Ctr, D-40225 Dusseldorf, Germany

[3] Univ Hosp Dusseldorf, Dept Gen Visceral & Pediat Surg, D-40225 Dusseldorf, Germany

来源：

HORMONE AND METABOLIC RESEARCH | 2011年 / 43卷 / 12期

关键词：

neuroendocrine malignancies; NET; tumor-immune-escape; immunoevasion; CELL LUNG-CANCER; HIGH-RISK NEUROBLASTOMA; MEDULLARY-THYROID CARCINOMA; REGULATORY T-CELLS; PHASE-I TRIAL; MHC CLASS-I; BONE-MARROW; DISEASE PROGRESSION; PERIPHERAL-BLOOD; PROGNOSTIC VALUE;

D O I：

10.1055/s-0031-1284382

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

During the last 30 years the incidence of neuroendocrine tumors has increased considerably and the overall 5-year survival rate has not changed substantially. Conventional therapeutic approaches appear to show an unsatisfactory effect in the more insidious forms of malignancies. Hence, attempts were made to direct the patient's own immune system against cancer by vaccinating against different tumor antigens. Up to date, only sporadic achievements were demonstrated in the majority cases of vaccination trials. One of the main hindrances to a successful vaccination comprises tumor-immune-escape mechanisms. This review focuses on the current knowledge concerning tumor immunoevasion strategies and the immune system in neuroendocrine tumors.

引用

页码：890 / 896

页数：7

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