The Catalytic Enantioselective Total Synthesis of (+)-Liphagal

被引：66

作者：

Day, Joshua J. ^{[1
,2
]}

McFadden, Ryan M. ^{[1
,2
]}

Virgil, Scott C. ^{[1
,2
]}

Kolding, Helene ^{[1
,2
]}

Alleva, Jennifer L. ^{[1
,2
]}

Stoltz, Brian M. ^{[1
,2
]}

机构：

[1] CALTECH, Warren & Katharine Schlinger Lab Chem & Chem Engn, Pasadena, CA 91125 USA

[2] CALTECH, Div Chem & Chem Engn, Caltech Ctr Catalysis & Chem Synth, Pasadena, CA 91125 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 30期

关键词：

arynes; asymmetric catalysis; natural products; terpenoids; total synthesis; ASYMMETRIC ALLYLIC ALKYLATION; PHOSPHOINOSITIDE 3-KINASE INHIBITORS; ALLYLATION REACTION; ENOL CARBONATES; QUATERNARY STEREOCENTERS; ALPHA-FLUOROKETONES; TSUJI ALLYLATION; ACYCLIC KETONES; LIPHAGAL; DECARBOXYLATION;

D O I：

10.1002/anie.201101842

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ring a ding: The meroterpenoid natural product (+)-liphagal has been synthesized enantioselectively in 19 steps from commercially available materials. The trans-homodecalin system was achieved by ring expansion followed by stereoselective hydrogenation. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6814 / 6818

页数：5

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