Enantioselective Total Synthesis of the Selective PI3 Kinase Inhibitor Liphagal

被引：40
|
作者：
Alvarez-Manzaneda, Enrique [1 ]
Chahboun, Rachid [1 ]
Alvarez, Esteban [1 ]
Cano, M. Jose [1 ]
Haidour, Ali [1 ]
Alvarez-Manzaneda, Ramon [2 ]
机构：
[1] Univ Granada, Fac Ciencias, Dept Quim Organ, Inst Biotecnol, E-18071 Granada, Spain
[2] Univ Almeria, Fac Ciencias, Dept Quim Organ, Almeria 04120, Spain
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 20期
关键词：
ABSOLUTE-CONFIGURATION; CYCLIZATION;
D O I：
10.1021/ol101173w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The enantioselective total synthesis of liphagal, a selective inhibitor of PI3K alpha isolated from the marine sponge Aka coralliphaga, has been achieved. The novel tetracyclic "liphagane" skeleton is formed in one step, after the hydrogenation of a dihydroxydrimane phenol benzyl ether in the presence of cationic resin.
引用
收藏
页码：4450 / 4453
页数：4
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